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Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma
TLDR
This study is the first to characterise gut microbiome in patients with HCC and to report the successful diagnosis model establishment and cross-region validation of microbial markers for HCC.
WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1
TLDR
This study is the first to report that WTAP-mediated m6A methylation has a crucial role in HCC oncogenesis, and highlights WTAP as a potential therapeutic target of HCC treatment.
Long Non-Coding RNA HOTAIR Promotes Cell Migration and Invasion via Down-Regulation of RNA Binding Motif Protein 38 in Hepatocellular Carcinoma Cells
TLDR
HOTAIR could promote migration and invasion of HCC cells by inhibiting RBM38, which indicated critical roles of HOTAIR and R BM38 in HCC progression.
O-GlcNAcylation plays a role in tumor recurrence of hepatocellular carcinoma following liver transplantation
TLDR
It is suggested that O-GlcNAcylation might play important roles in HCC formation and progression and may be a potential marker to predict patient risk of recurrence after LT and a valuable target for therapy.
ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1
TLDR
This study reveals that ALKBH5, characterized as a tumor suppressor, attenuates the expression of LYPD1 via an m6A-dependent manner in HCC cells, and provides new insights into potential biomarkers and therapeutic targets of HCC treatment.
Involvement of Th17 and Th1 Effector Responses in Patients with Hepatitis B
TLDR
The results suggest that the balance of effector CD4+ Th responses (Th17 and Th1 responses) and regulatory response is an important element of immune regulation.
Liver transplantation for hepatocellular carcinoma beyond the Milan criteria
TLDR
The prognostic stratification system based on the Hangzhou criteria serves as a hierarchy of transplant candidates for hepatocellular carcinoma and shows excellent efficiency in recurrence prediction for the expanded criteria compared with the Milan criteria.
Interaction of B7‐H1 on intrahepatic cholangiocarcinoma cells with PD‐1 on tumor‐infiltrating T cells as a mechanism of immune evasion
TLDR
This study aimed to investigate the expression of B7‐H1 and its receptor PD‐1 and to explore their significance in the progression of intraheptic cholangiocarcinoma (ICC).
Long non-coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients
TLDR
The high expression levels of PVT1 in HCC may serve as a novel biomarker for predicting tumor recurrence in H CC patients, and as a potential therapeutic target.
Blocking Triggering Receptor Expressed on Myeloid Cells‐1‐Positive Tumor‐Associated Macrophages Induced by Hypoxia Reverses Immunosuppression and Anti‐Programmed Cell Death Ligand 1 Resistance in
TLDR
It is highlighted that the hypoxic environment initiated the onset of tumor immunosuppression through TREM‐1+ TAMs attracting CCR6+Foxp3+ Tregs, and TREM-1- TAMs endowed HCC with anti‐PD‐L1 therapy resistance.
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