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Mitochondrial Fission

Known as: Mitochondrial Fissions, Fission, Mitochondrial, Fissions, Mitochondrial 
The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [PMID:11038192]
National Institutes of Health

Related topics

Related topics

6 relations

Broader (1)

Mitochondrial Dynamics

Narrower (4)

establishment of protein localization to mitochondrial membrane involved in mitochondrial fissionmitochondrial DNA inheritancemitochondrial membrane fissionmitochondrial nucleoid organization involved in mitochondrial fission
regulation of mitochondrial fission

Papers overview

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Highly Cited
2011
Highly Cited
2011
ER Tubules Mark Sites of Mitochondrial Division
Mitochondrial division occurs at positions where endoplasmic reticulum tubules contact mitochondria and mediate constriction… Expand
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Highly Cited
2010
Highly Cited
2010
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells
Localization of the dynamin-related GTPase Drp1 to mitochondria relies on the mitochondrial fission factor Mff. 
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Highly Cited
2010
Highly Cited
2010
Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury.
BACKGROUND Whether alterations in mitochondrial morphology affect the susceptibility of the heart to ischemia/reperfusion injury… Expand
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Highly Cited
2009
Highly Cited
2009
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD) neurons. In this study, we explored the involvement… Expand
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Highly Cited
2009
Highly Cited
2009
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
Mitochondrial morphology is dynamically controlled by a balance between fusion and fission. The physiological importance of… Expand
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Highly Cited
2009
Highly Cited
2009
Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission*
Mitochondrial dysregulation is strongly implicated in Parkinson disease. Mutations in PTEN-induced kinase 1 (PINK1) are… Expand
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Highly Cited
2009
Highly Cited
2009
S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Mitochondria continuously undergo two opposing processes, fission and fusion. The disruption of this dynamic equilibrium may… Expand
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Highly Cited
2007
Highly Cited
2007
Mitotic Phosphorylation of Dynamin-related GTPase Drp1 Participates in Mitochondrial Fission*
Organelles are inherited to daughter cells beyond dynamic changes of the membrane structure during mitosis. Mitochondria are… Expand
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Highly Cited
2004
Highly Cited
2004
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.
During apoptosis, the mitochondrial network fragments. Using short hairpin RNAs for RNA interference, we manipulated the… Expand
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Highly Cited
2001
Highly Cited
2001
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.
In healthy cells, fusion and fission events participate in regulating mitochondrial morphology. Disintegration of the… Expand
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