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Mitochondrial Fission

Known as: Mitochondrial Fissions, Fission, Mitochondrial, Fissions, Mitochondrial 
The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments. [PMID:11038192]

Topic mentions per year

Topic mentions per year

1964-2018
05010015019642018

Related topics

Related topics

4 relations

Broader (1)

Mitochondrial Dynamics

Narrower (2)

mitochondrial DNA inheritancemitochondrial membrane fission
regulation of mitochondrial fission

Related mentions per year

Related mentions per year

1964-2018
1960198020002020
Mitochondrial Fission
Mitochondrial Dynamics
mitochondrial DNA inheritance
regulation of mitochondrial fission
mitochondrial membrane fission

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Inhibiting mitochondrial fission protects the heart against ischemia/reperfusion injury.
BACKGROUND Whether alterations in mitochondrial morphology affect the susceptibility of the heart to ischemia/reperfusion injury… (More)
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Highly Cited
2009
Highly Cited
2009
Impaired balance of mitochondrial fission and fusion in Alzheimer's disease.
Mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD) neurons. In this study, we explored the involvement… (More)
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Highly Cited
2009
Highly Cited
2009
S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.
Mitochondria continuously undergo two opposing processes, fission and fusion. The disruption of this dynamic equilibrium may… (More)
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Highly Cited
2009
Highly Cited
2009
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission.
Mitochondrial dysregulation is strongly implicated in Parkinson disease. Mutations in PTEN-induced kinase 1 (PINK1) are… (More)
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Highly Cited
2009
Highly Cited
2009
Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice
Mitochondrial morphology is dynamically controlled by a balance between fusion and fission. The physiological importance of… (More)
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Highly Cited
2007
Highly Cited
2007
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.
Organelles are inherited to daughter cells beyond dynamic changes of the membrane structure during mitosis. Mitochondria are… (More)
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Highly Cited
2004
Highly Cited
2004
Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.
During apoptosis, the mitochondrial network fragments. Using short hairpin RNAs for RNA interference, we manipulated the… (More)
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Highly Cited
2003
Highly Cited
2003
hFis1, a novel component of the mammalian mitochondrial fission machinery.
The balance between the fission and fusion mechanisms regulate the morphology of mitochondria. In this study we have identified a… (More)
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Highly Cited
2001
Highly Cited
2001
The role of dynamin-related protein 1, a mediator of mitochondrial fission, in apoptosis.
In healthy cells, fusion and fission events participate in regulating mitochondrial morphology. Disintegration of the… (More)
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Highly Cited
1999
Highly Cited
1999
The dynamin-related GTPase Dnm1 regulates mitochondrial fission in yeast
The dynamin-related GTPase Dnm1 controls mitochondrial morphology in yeast. Here we show that dnm1 mutations convert the… (More)
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