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Minocycline

Known as: (4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, Minocyclin, 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,12aalpha))- 
A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
BackgroundActivation of the peripheral innate immune system stimulates the secretion of CNS cytokines that modulate the… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Minocycline has anti-apoptotic and anti-inflammatory effects in vitro, and extends survival in mouse models of some… Expand
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Highly Cited
2005
Highly Cited
2005
Activated glial cells (microglia and astroglia) in the spinal cord play a major role in mediating enhanced pain states by… Expand
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Highly Cited
2004
Highly Cited
2004
Minocycline has been demonstrated to be neuroprotective after spinal cord injury (SCI). However, the cellular consequences of… Expand
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Highly Cited
2002
Highly Cited
2002
Minocycline mediates neuroprotection in experimental models of neurodegeneration. It inhibits the activity of caspase-1, caspase… Expand
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Highly Cited
2002
Highly Cited
2002
Multiple sclerosis is characterized by the infiltration of leukocytes into the CNS. As matrix metalloproteinases (MMPs… Expand
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Highly Cited
2001
Highly Cited
2001
Minocycline, a semisynthetic tetracycline derivative, protects brain against global and focal ischemia in rodents. We examined… Expand
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Highly Cited
2001
Highly Cited
2001
Glutamate excitotoxicity to a large extent is mediated through activation of the N-methyl-d-aspartate (NMDA)-gated ion channels… Expand
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Highly Cited
2000
Highly Cited
2000
Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline… Expand
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Highly Cited
1999
Highly Cited
1999
The only treatment of patients with acute ischemic stroke is thrombolytic therapy, which benefits only a fraction of stroke… Expand
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