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Minocycline

Known as: (4S,4AS,5ar,12as)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, Minocyclin, 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,12aalpha))- 
A TETRACYCLINE analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant… 
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (18)

9-(N,N-dimethylglycylamido)minocyclineAkne-PurenAknin-MinoArestin
Acne VulgarisAnthrax diseaseHypersensitivityIn Blood

Broader (2)

Anti-Bacterial AgentsTetracycline Antibiotics

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Trial of Minocycline in a Clinically Isolated Syndrome of Multiple Sclerosis
BACKGROUND On the basis of encouraging preliminary results, we conducted a randomized, controlled trial to determine whether… 
Highly Cited
2013
Highly Cited
2013
A Randomized Double-Blind, Placebo-Controlled Trial of Minocycline in Children and Adolescents with Fragile X Syndrome
Objective: Minocycline rescued synaptic abnormalities and improved behavior in the fragile X mouse model. Previous open-label… 
Highly Cited
2006
Highly Cited
2006
Delayed Transplantation of Adult Neural Precursor Cells Promotes Remyelination and Functional Neurological Recovery after Spinal Cord Injury
Spinal cord injury (SCI) results in loss of oligodendrocytes demyelination of surviving axons and severe functional impairment… 
Review
2005
Review
2005
Clinical heterogeneity of drug hypersensitivity.
Review
2005
Review
2005
Calcinosis in rheumatic diseases.
Review
2004
Review
2004
Inflammation and apoptosis: linked therapeutic targets in spinal cord injury.
Highly Cited
2003
Highly Cited
2003
Minocycline enhances MPTP toxicity to dopaminergic neurons
Minocycline has been shown previously to have beneficial effects against ischemia in rats as well as neuroprotective properties… 
Highly Cited
2003
Highly Cited
2003
Treatment of cutaneous calcinosis in limited systemic sclerosis with minocycline
Objectives: To evaluate the effect of minocycline as treatment for cutaneous calcinosis in limited cutaneous systemic sclerosis… 
Review
1998
Review
1998
Tn916 Family Conjugative Transposons and Dissemination of Antimicrobial Resistance Determinants
The widespread use of broad-spectrum antimicrobial agents poses a significant challenge to bacteria pathogenic for humans, a… 
Highly Cited
1975
Highly Cited
1975
Relation Between Lipophilicity and Pharmacological Behavior of Minocycline, Doxycycline, Tetracycline, and Oxytetracycline in Dogs
Four tetracyclines were studied in dogs to determine the relation between their lipophilicity and various other pharmacological… 
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