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Mifepristone

Known as: (aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, Mifepristone [Chemical/Ingredient], Mifepristonum 
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early… 
National Institutes of Health

Related topics

Related topics

38 relations
Abortifacient AgentsAdnexal DiseasesAdrenal Cortex DiseasesBrain Neoplasms

Broader (7)

Abortifacient Agents, SteroidalContraceptive Agents, FemaleContraceptives, Postcoital, SyntheticEstranes

Narrower (12)

MifegyneMifeprexR-38486RU 40555

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Rapid nongenomic inhibitory effects of glucocorticoids on phagocytosis and superoxide anion production by macrophages
Review
2003
Review
2003
Pharmacologic properties of CDB(VA)-2914
Highly Cited
2001
Highly Cited
2001
Dexamethasone induces limited apoptosis and extensive sublethal damage to specific subregions of the striatum and hippocampus: implications for mood disorders
Highly Cited
2001
Highly Cited
2001
Long‐term mifepristone (RU486) therapy resulting in massive benign endometrial hyperplasia
Mifepristone (RU486) is a potent antiprogestagen, and at high doses it also acts as an antiglucocorticoid drug. Mifepristone… 
Review
1999
Review
1999
Misoprostol used alone for the termination of early pregnancy. A review of the evidence.
Highly Cited
1999
Highly Cited
1999
Early abortion with 800 μg of misoprostol by the vaginal route
Highly Cited
1995
Highly Cited
1995
Effects of dexamethasone on protein degradation and protease gene expression in rat L8 myotube cultures
Review
1992
Review
1992
Progesterone antagonists: Tumor-inhibiting potential and mechanism of action
Highly Cited
1990
Highly Cited
1990
Termination of pregnancy and induction of premature luteolysis by the antiprogestagen, mifepristone, in dogs.
Five pregnant beagle bitches were treated with 2.5 mg mifepristone/kg body weight, twice a day, for 4.5 days starting at Day 32… 
Highly Cited
1989
Highly Cited
1989
The antitumor mechanism of progesterone antagonists is a receptor mediated antiproliferative effect by induction of terminal cell death.
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