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Mifepristone
Known as:
(aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
, Mifepristone [Chemical/Ingredient]
, Mifepristonum
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A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early…
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National Institutes of Health
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Related topics
Related topics
38 relations
Abortifacient Agents
Adnexal Diseases
Adrenal Cortex Diseases
Brain Neoplasms
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Broader (7)
Abortifacient Agents, Steroidal
Contraceptive Agents, Female
Contraceptives, Postcoital, Synthetic
Estranes
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Narrower (12)
Mifegyne
Mifeprex
R-38486
RU 40555
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome.
M. Fleseriu
,
B. Biller
,
J. Findling
,
M. Molitch
,
D. Schteingart
,
Coleman Gross
The Journal of clinical endocrinology and…
2012
Corpus ID: 30934442
CONTEXT Cushing's syndrome (CS) is a disorder associated with significant morbidity and mortality due to prolonged exposure to…
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Highly Cited
2007
Highly Cited
2007
Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats
B. Aisa
,
R. Tordera
,
B. Lasheras
,
J. Rı́o
,
M. Ramírez
Psychoneuroendocrinology
2007
Corpus ID: 17312894
Highly Cited
2006
Highly Cited
2006
Long-Term Administration of Mifepristone (RU486): Clinical Tolerance During Extended Treatment of Meningioma
S. Grunberg
,
M. Weiss
,
+4 authors
R. Sitruk-Ware
Cancer investigation
2006
Corpus ID: 12521497
Background: Mifepristone (RU486) is an oral antiprogestational and, to a lesser extent, antiglucocorticoid agent commonly used…
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Highly Cited
2004
Highly Cited
2004
Improvements in Neurocognitive Function and Mood Following Adjunctive Treatment with Mifepristone (RU-486) in Bipolar Disorder
A. Young
,
P. Gallagher
,
S. Watson
,
D. Del-Estal
,
B. M. Owen
,
I. Ferrier
Neuropsychopharmacology
2004
Corpus ID: 23262188
High cortisol levels are found in severe mood disorders, particularly bipolar disorder. Hypercortisolaemia may cause or…
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Highly Cited
2003
Highly Cited
2003
The production and characteristics of solid lipid nanoparticles (SLNs).
Dongzhi Hou
,
C. Xie
,
Kai Huang
,
Changhong Zhu
Biomaterials
2003
Corpus ID: 35127058
Review
2002
Review
2002
Sleep and the hypothalamo-pituitary-adrenocortical system.
A. Steiger
Sleep medicine reviews
2002
Corpus ID: 1955250
The intention of this review is to summarize the current knowledge on the bidirectional interaction between sleep EEG and the…
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Review
2001
Review
2001
Rapid Reversal of Psychotic Depression Using Mifepristone
J. Belanoff
,
Benjamin H. Flores
,
Michelle Kalezhan
,
B. Sund
,
A. Schatzberg
Journal of clinical psychopharmacology
2001
Corpus ID: 3067889
The rationale for treating psychotic major depression with glucocorticoid receptor (GR) antagonists is reviewed. Five patients…
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Highly Cited
1998
Highly Cited
1998
Early pregnancy termination with mifepristone and misoprostol in the United States.
I. Spitz
,
C. Bardin
,
L. Benton
,
A. Robbins
The New England journal of medicine
1998
Corpus ID: 28396239
BACKGROUND Mifepristone and a prostaglandin have been used successfully to terminate pregnancy in Europe and China. We report the…
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Review
1997
Review
1997
RU486 (mifepristone): mechanisms of action and clinical uses.
F. Cadepond
,
A. Ulmann
,
E. Baulieu
Annual review of medicine
1997
Corpus ID: 22713872
RU486 (mifepristone) has proved to be a remarkably active antiprogesterone and antiglucocorticosteroid agent in human beings. The…
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Highly Cited
1991
Highly Cited
1991
Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone.
S. Grunberg
,
M. Weiss
,
+5 authors
L. L. Stevenson
Journal of neurosurgery
1991
Corpus ID: 43520897
The possibility that meningioma growth may be related to female sex hormone levels is suggested by several lines of evidence…
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