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Mifepristone

Known as: (aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one, Mifepristone [Chemical/Ingredient], Mifepristonum 
A progestational and glucocorticoid hormone antagonist. Its inhibition of progesterone induces bleeding during the luteal phase and in early… 
National Institutes of Health

Related topics

Related topics

38 relations
Abortifacient AgentsAdnexal DiseasesAdrenal Cortex DiseasesBrain Neoplasms

Broader (7)

Abortifacient Agents, SteroidalContraceptive Agents, FemaleContraceptives, Postcoital, SyntheticEstranes

Narrower (12)

MifegyneMifeprexR-38486RU 40555

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Mifepristone, a glucocorticoid receptor antagonist, produces clinical and metabolic benefits in patients with Cushing's syndrome.
CONTEXT Cushing's syndrome (CS) is a disorder associated with significant morbidity and mortality due to prolonged exposure to… 
Highly Cited
2007
Highly Cited
2007
Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats
Highly Cited
2006
Highly Cited
2006
Long-Term Administration of Mifepristone (RU486): Clinical Tolerance During Extended Treatment of Meningioma
Background: Mifepristone (RU486) is an oral antiprogestational and, to a lesser extent, antiglucocorticoid agent commonly used… 
Highly Cited
2004
Highly Cited
2004
Improvements in Neurocognitive Function and Mood Following Adjunctive Treatment with Mifepristone (RU-486) in Bipolar Disorder
High cortisol levels are found in severe mood disorders, particularly bipolar disorder. Hypercortisolaemia may cause or… 
Highly Cited
2003
Highly Cited
2003
The production and characteristics of solid lipid nanoparticles (SLNs).
Review
2002
Review
2002
Sleep and the hypothalamo-pituitary-adrenocortical system.
  • A. Steiger
  • Sleep medicine reviews
  • 2002
  • Corpus ID: 1955250
The intention of this review is to summarize the current knowledge on the bidirectional interaction between sleep EEG and the… 
Review
2001
Review
2001
Rapid Reversal of Psychotic Depression Using Mifepristone
The rationale for treating psychotic major depression with glucocorticoid receptor (GR) antagonists is reviewed. Five patients… 
Highly Cited
1998
Highly Cited
1998
Early pregnancy termination with mifepristone and misoprostol in the United States.
BACKGROUND Mifepristone and a prostaglandin have been used successfully to terminate pregnancy in Europe and China. We report the… 
Review
1997
Review
1997
RU486 (mifepristone): mechanisms of action and clinical uses.
RU486 (mifepristone) has proved to be a remarkably active antiprogesterone and antiglucocorticosteroid agent in human beings. The… 
Highly Cited
1991
Highly Cited
1991
Treatment of unresectable meningiomas with the antiprogesterone agent mifepristone.
The possibility that meningioma growth may be related to female sex hormone levels is suggested by several lines of evidence… 
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