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Microsatellite Mutator Phenotype

A genetic marker phenotype found in some cancers, this condition is marked by the presence of hundreds to thousands of mutations in microsatellite… 
National Institutes of Health

Papers overview

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2004
2004
Topoisomerase II gene mutations in tumors and tumor cell lines with microsatellite instability.
Highly Cited
2003
Highly Cited
2003
Tumors with microsatellite instability: many mutations, targets and paradoxes
Tumors of the microsatellite mutator phenotype (MMP) accumulate hundreds of thousands of somatic clonal mutations, preferentially… 
Review
2002
Review
2002
Gastrointestinal cancer of the microsatellite mutator phenotype pathway
transforming growth factor (TGF) receptor type II (TGF RII)7 and BAX.8 These mutations are absent in cancers that are MMP… 
2002
2002
Low mutation incidence in polymorphic noncoding short mononucleotide repeats in gastrointestinal cancer of the microsatellite mutator phenotype pathway.
Frameshifts in short mononucleotide tracts (SMT) in genes, such as TGFbetaRII and BAX, are common in gastrointestinal tumors of… 
2001
2001
Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype
Genetic or epigenetic inactivation of one of the DNA mismatch repair (MMR) genes in tumor precursor cells causes a profound… 
2001
2001
Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype
BackgroundGenomic instability has been reported at microsatellite tracts in few coding sequences. We have shown that the Bloom… 
Highly Cited
2000
Highly Cited
2000
Mutational inactivation of the proapoptotic gene BAX confers selective advantage during tumor clonal evolution.
A remarkable instability at simple repeated sequences characterizes gastrointestinal cancer of the microsatellite mutator… 
Highly Cited
1999
Highly Cited
1999
Gastric cancers of the microsatellite mutator phenotype display characteristic genetic and clinical features.
Highly Cited
1998
Highly Cited
1998
Somatic frameshift mutations in DNA mismatch repair and proapoptosis genes in hereditary nonpolyposis colorectal cancer.
An exacerbated genomic instability at simple repeated sequences characterizes cancer of the microsatellite mutator phenotype (MMP… 
1995
1995
The microsatellite mutator phenotype of colon cancer cells is often recessive.
A new mutator mechanism for tumorigenesis, characterized by somatic genomic instability (SGI) at simple repeated sequences (SRS… 
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