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Microsatellite Mutator Phenotype

A genetic marker phenotype found in some cancers, this condition is marked by the presence of hundreds to thousands of mutations in microsatellite… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Correlation of MLH1 and MGMT methylation levels between peripheral blood leukocytes and colorectal tissue DNA samples in colorectal cancer patients
CpG island methylation in the promoter regions of the DNA mismatch repair gene mutator L homologue 1 (MLH1) and DNA repair gene… 
2004
2004
Topoisomerase II gene mutations in tumors and tumor cell lines with microsatellite instability.
2002
2002
Molecular alteration of gastric carcinoma.
Gastric cancer is constituted by two histomorphological entities ''intestinal'' and ''diffuse'' that differ in epidemiology… 
2001
2001
Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype
BackgroundGenomic instability has been reported at microsatellite tracts in few coding sequences. We have shown that the Bloom… 
2000
2000
Genotyping of frameshift mutations in colorectal cancer (CRC) of the microsatellite mutator phenotype (MMP)
1999
1999
Frameshift mutations in TGFbetaRII, IGFIIR, BAX, hMSH3 and hMSH6 are absent in lung cancers.
A genome-wide instability at simple repeat sequences characterizes gastrointestinal and endometrial cancers of the microsatellite… 
1998
1998
Mutations of the human MUT S homologue 6 gene in ampullary carcinoma and gastric cancer
MSH6 has been implicated in repair of single base mispairs and single‐base deletion/insertion mutations. Established MSH6‐null… 
1997
1997
Frequent alterations in gene expression in colon tumor cells of the microsatellite mutator phenotype.
1996
1996
Detection of microsatellite instability in cancers by arbitrarily primed-PCR fingerprinting using a fluorescently labeled primer (FAP-PCR).
The microsatellite mutator phenotype (MMP), detected as a change in the number of repeating units in hundreds of thousands of… 
1995
1995
The microsatellite mutator phenotype of colon cancer cells is often recessive.
A new mutator mechanism for tumorigenesis, characterized by somatic genomic instability (SGI) at simple repeated sequences (SRS… 
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