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Microbicides, Topical

Known as: Microbicides, Local, topical microbicide, topical microbicides 
Generically, any topical agent that destroys microbes. However, usage of the term is increasingly being confined to topical agents that prevent or… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Anti-Infective AgentsAnti-Infective Agents, Local

Papers overview

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Review
2011
Review
2011
Clinical significance of HIV-1 coreceptor usage
The identification of phenotypically distinct HIV-1 variants with different prevalence during the progression of the disease has… 
Highly Cited
2010
Highly Cited
2010
Inhibition of bacterial growth and intramniotic infection in a guinea pig model of chorioamnionitis using PAMAM dendrimers.
Review
2007
Review
2007
Pre-exposure prophylaxis for HIV infection: what if it works?
Highly Cited
2007
Highly Cited
2007
Preclinical Testing of Candidate Topical Microbicides for Anti-Human Immunodeficiency Virus Type 1 Activity and Tissue Toxicity in a Human Cervical Explant Culture
ABSTRACT A human cervical explant culture was utilized for the preclinical assessment of anti-human immunodeficiency virus type 1… 
Highly Cited
2005
Highly Cited
2005
The antimicrobial peptide dermaseptin S4 inhibits HIV-1 infectivity in vitro.
Highly Cited
2005
Highly Cited
2005
Candidate Sulfonated and Sulfated Topical Microbicides: Comparison of Anti-Human Immunodeficiency Virus Activities and Mechanisms of Action
ABSTRACT Poly(styrene 4-sulfonate), cellulose sulfate, polymethylenehydroquinone, and PRO 2000 are sulfated or sulfonated… 
Highly Cited
2005
Highly Cited
2005
SPL7013 gel as a topical microbicide for prevention of vaginal transmission of SHIV89.6P in macaques.
SPL7013 is a dendrimer with a polyanionic outer surface that allows multiple interactions with target sites. It potently binds… 
Review
2004
Review
2004
Clinical development of microbicides for the prevention of HIV infection.
The HIV/AIDS pandemic continues its spread at a rate of over 15,000 new infections every day. Sexual transmission of HIV-1 is the… 
Highly Cited
2004
Highly Cited
2004
Candidate Topical Microbicides Bind Herpes Simplex Virus Glycoprotein B and Prevent Viral Entry and Cell-to-Cell Spread
ABSTRACT Topical microbicides designed to prevent acquisition of sexually transmitted infections are urgently needed. Nonoxynol-9… 
Highly Cited
2003
Highly Cited
2003
Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques.
Cyanovirin-N (CV-N), an 11-kDa cyanobacterial protein, potently inactivates diverse strains of HIV-1, HIV-2, and simian… 
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