Mice, Transgenic

Known as: Transgenic mice, mouse transgenics, Mouse, Transgenic 
A mouse whose genome has been altered by the inclusion of foreign genetic material. The technique involves microinjection of foreign DNA fragments… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Hyperphosphorylated tau makes up the filamentous intracellular inclusions of several neurodegenerative diseases, including… (More)
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Highly Cited
2004
Highly Cited
2004
Macroautophagy mediates the bulk degradation of cytoplasmic components. It accounts for the degradation of most long-lived… (More)
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Highly Cited
2003
Highly Cited
2003
Genetically encoded antibiotic peptides are evolutionarily ancient and widespread effector molecules of immune defence. Mammalian… (More)
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Highly Cited
2001
Highly Cited
2001
Inflammation in Alzheimer's disease (AD) patients is characterized by increased cytokines and activated microglia… (More)
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Highly Cited
2000
Highly Cited
2000
Amyloid plaques are a neuropathological hallmark of Alzheimer's disease (AD), but their relationship to neurodegeneration and… (More)
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Highly Cited
2000
Highly Cited
2000
Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline… (More)
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Highly Cited
1997
Highly Cited
1997
Mutations in the amyloid precursor protein (APP) gene cause early-onset familial Alzheimer disease (AD) by affecting the… (More)
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Highly Cited
1997
Highly Cited
1997
The green fluorescent protein (GFP) is responsible for the green bioluminescence of the jellyfish Aequorea victoria. Many classes… (More)
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Highly Cited
1991
Highly Cited
1991
We have generated transgenic mouse lines carrying and expressing wild-type and 3'-modified human tumour necrosis factor (hTNF… (More)
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Highly Cited
1990
Highly Cited
1990
Plasmids comprising transgene insertions in four lines of transgenic mice have been retrieved by plasmid rescue into a set of… (More)
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