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Mice, Transgenic

Known as: Transgenic mice, mouse transgenics, Mouse, Transgenic 
A mouse whose genome has been altered by the inclusion of foreign genetic material. The technique involves microinjection of foreign DNA fragments… 
National Institutes of Health

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Animals, Genetically ModifiedGenetic EngineeringIn BloodLaboratory mice

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Founder Mice, Transgenic

Papers overview

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Highly Cited
2012
Highly Cited
2012
Prion-like acceleration of a synucleinopathy in a transgenic mouse model
Review
2011
Review
2011
Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
Highly Cited
2001
Highly Cited
2001
Expression of interleukin-4 in the epidermis of transgenic mice results in a pruritic inflammatory skin disease: an experimental animal model to study atopic dermatitis.
Atopic dermatitis, a common, chronic, inflammatory skin disease that occurs with increasing prevalence, is characterized by… 
Highly Cited
2000
Highly Cited
2000
Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes
To examine the normal cellular function of tau and its role in pathogenesis, we have created transgenic mice that overexpress a… 
Highly Cited
2000
Highly Cited
2000
A Filarial Nematode-Secreted Product Signals Dendritic Cells to Acquire a Phenotype That Drives Development of Th2 Cells1
Although exogeneous “danger” signals such as LPS can activate APC to produce a Th1 response, the nature of events initiating a… 
Highly Cited
2000
Highly Cited
2000
Eradication of established tumors by CD8+ T cell adoptive immunotherapy.
Highly Cited
2000
Highly Cited
2000
Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.
We have previously shown that antibodies to CTLA-4, an inhibitory receptor on T cells, can be effective at inducing regression of… 
Highly Cited
2000
Highly Cited
2000
A novel reporter mouse strain that expresses enhanced green fluorescent protein upon Cre‐mediated recombination
Highly Cited
1994
Highly Cited
1994
A mutant neurofilament subunit causes massive, selective motor neuron death: Implications for the pathogenesis of human motor neuron disease
Review
1989
Review
1989
Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes
B lymphocytes can be rendered specifically unresponsive to antigen by experimental manipulation in vivo and in vitro1–6, but it… 
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