Skip to search formSkip to main contentSkip to account menu

Mibefradil

Known as: (1S,2S)-(2-((3-(2-Benzimidazolyl)Propyl)Methylamino)Ethyl)-6-Fluoro-1,2,3,4-Tetrahydro-1-Isopropyl-2-Naphthyl Methoxyacetate, Acetic acid, methoxy-, 2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, (1S-cis)-, Mibefradil [Chemical/Ingredient] 
A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.
National Institutes of Health

Related topics

Related topics

16 relations
Angina PectorisDecreased Blood Pressure [PE]Hypertensive diseaseIn Blood

Broader (3)

Antihypertensive AgentsCalcium Channel BlockersVasodilator Agents

Narrower (3)

Mibefradil DihydrochloridePosicorRo 40-5967

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitors.
Highly Cited
2001
Highly Cited
2001
Redox Modulation of T-Type Calcium Channels in Rat Peripheral Nociceptors
Highly Cited
2001
Highly Cited
2001
T-Type Ca2+ Channels Mediate Neurotransmitter Release in Retinal Bipolar Cells
Highly Cited
1998
Highly Cited
1998
Life-threatening interaction of mibefradil and beta-blockers with dihydropyridine calcium channel blockers.
Mibefradil is a T-type and L-type calcium channel blocker (CCB) released in the United States in 1997 for management of… 
Highly Cited
1997
Highly Cited
1997
Contrasting biophysical and pharmacological properties of T-type and R-type calcium channels
Review
1997
Review
1997
Discovery and main pharmacological properties of mibefradil (Ro 40‐5967), the first selective T‐type calcium channel blocker
Properties of mibefradil Mibefradil is a novel calcium channel antagonist with structural and pharmacological characteristics… 
Highly Cited
1995
Highly Cited
1995
Voltage-dependent blockade of diverse types of voltage-gated Ca2+ channels expressed in Xenopus oocytes by the Ca2+ channel antagonist mibefradil (Ro 40-5967).
Four different types of Ca2+ channel alpha 1 subunits, representing the major classes of voltage-gated Ca2+ channels, were… 
Highly Cited
1994
Highly Cited
1994
Selective inhibition of T-type Ca2+ channels by Ro 40-5967.
The present study shows that the chemically novel nondihydropyridine Ca2+ antagonist, Ro 40-5967, blocks T-type divalent ion… 
Highly Cited
1994
Highly Cited
1994
The Ca(++)-channel blocker Ro 40-5967 blocks differently T-type and L-type Ca++ channels.
The effects of Ro 40-5967, a nondihydropyridine Ca++ channel blocker, on low-voltage activated (T-type) and high-voltage… 
Highly Cited
1990
Highly Cited
1990
The proliferative response to vascular injury is suppressed by angiotensin-converting enzyme inhibition.
Smooth muscle cell (SMC) proliferation and formation of extracellular matrix in the intima of muscular arteries are major… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)