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Mibefradil

Known as: (1S,2S)-(2-((3-(2-Benzimidazolyl)Propyl)Methylamino)Ethyl)-6-Fluoro-1,2,3,4-Tetrahydro-1-Isopropyl-2-Naphthyl Methoxyacetate, Acetic acid, methoxy-, 2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, (1S-cis)-, Mibefradil [Chemical/Ingredient] 
A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.
National Institutes of Health

Related topics

Related topics

16 relations
Angina PectorisDecreased Blood Pressure [PE]Hypertensive diseaseIn Blood

Broader (3)

Antihypertensive AgentsCalcium Channel BlockersVasodilator Agents

Narrower (3)

Mibefradil DihydrochloridePosicorRo 40-5967

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
3D pharmacophore based virtual screening of T-type calcium channel blockers.
Highly Cited
2005
Highly Cited
2005
Antihypertensive Effects of the Putative T-Type Calcium Channel Antagonist Mibefradil Are Mediated by the L-Type Calcium Channel Cav1.2
The role of T-type Ca2+ channels for cardiovascular physiology, in particular blood pressure regulation, is controversial… 
2004
2004
3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.
Review
2002
Review
2002
Pharmacological interactions of statins.
Highly Cited
2001
Highly Cited
2001
T-Type Ca2+ Channels Mediate Neurotransmitter Release in Retinal Bipolar Cells
Highly Cited
2001
Highly Cited
2001
Role of membrane depolarization and T-type Ca2+ channels in angiotensin II and K+ stimulated aldosterone secretion
Highly Cited
2001
Highly Cited
2001
L-type and T-type calcium channel blockade potentiate the analgesic effects of morphine and selective μ opioid agonist, but not to selective δ and κ agonist at the level of the spinal cord in mice
Highly Cited
2000
Highly Cited
2000
Mechanisms of hydrogen peroxide-induced calcium dysregulation in PC12 cells.
Highly Cited
2000
Highly Cited
2000
Inhibition of angiogenesis by blockers of volume-regulated anion channels.
Highly Cited
1996
Highly Cited
1996
Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats.
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