Mibefradil

Known as: (1S,2S)-(2-((3-(2-Benzimidazolyl)Propyl)Methylamino)Ethyl)-6-Fluoro-1,2,3,4-Tetrahydro-1-Isopropyl-2-Naphthyl Methoxyacetate, Acetic acid, methoxy-, 2-(2-((3-(1H-benzimidazol-2-yl)propyl)methylamino)ethyl)-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl ester, (1S-cis)-, Mibefradil [Chemical/Ingredient] 
A benzimidazoyl-substituted tetraline that selectively binds and inhibits CALCIUM CHANNELS, T-TYPE.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
020406019892017

Papers overview

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2004
2004
Mibefradil is a T-type Ca2+ channel antagonist with reported cross-reactivity with other classes of ion channels, including K… (More)
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2003
2003
Mibefradil, a calcium channel blocker, was removed from the market because of adverse drug interactions with coadministered… (More)
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Highly Cited
2002
Highly Cited
2002
Dopaminergic midbrain (DA) neurons display two principal activity patterns in vivo, single-spike and burst firing, the latter… (More)
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Highly Cited
2000
Highly Cited
2000
Mibefradil is a tetralol derivative chemically distinct from other calcium channel antagonists. It is a very effective… (More)
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Highly Cited
1999
Highly Cited
1999
Acutely dissociated cell bodies of mouse Purkinje neurons spontaneously fired action potentials at approximately 50 Hz (25… (More)
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Highly Cited
1998
Highly Cited
1998
The antihypertensive agent mibefradil completely and reversibly inhibited T-type calcium channels in freshly isolated rat… (More)
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Highly Cited
1998
Highly Cited
1998
Voltage-activated Ca2+ channels exist as multigene families that share common structural features. Different Ca2+ channels are… (More)
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Highly Cited
1995
Highly Cited
1995
Four different types of Ca2+ channel alpha 1 subunits, representing the major classes of voltage-gated Ca2+ channels, were… (More)
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Highly Cited
1994
Highly Cited
1994
The present study shows that the chemically novel nondihydropyridine Ca2+ antagonist, Ro 40-5967, blocks T-type divalent ion… (More)
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1994
1994
The effects of Ro 40-5967, a nondihydropyridine Ca++ channel blocker, on low-voltage activated (T-type) and high-voltage… (More)
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