Methylhistamines

6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) is a novel… Expand

Mastocytosis is characterized by the abnormal proliferation of mast cells in 1 or more organs. In most patients, a mutation is… Expand

Background  Histamine is one of the most common chemical mediators causing pruritus, and H1 receptor antagonists have been used… Expand

Histamine (0.004–2 μM) induced a concentration‐dependent shape change of human eosinophils, but not of neutrophils or basophils… Expand

Background: Although there is increasing evidence of the importance of cysteinyl leukotrienes (LT) as mediators of aspirin… Expand

A new histamine receptor, HH4R, was cloned from human leukocyte cDNA. The deduced amino acid sequence showed about 40% identity… Expand

It is generally accepted that the early asthmatic response to inhaled allergen is a result of IgE‐mediated mast cell activation… Expand

AL-4943A (Olopatadine) is a new antihistaminic and anti-allergic drug. It was tested for its ability to compete for [3H… Expand

1 The pharmacological properties and location of H3 receptors modulating acetylcholine release have been investigated in non… Expand

1 The effect of agents which interact with the histamine H3 receptor on potassium‐stimulated tritium release from slices of rat… Expand