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6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) is a novel… Expand Mastocytosis is characterized by the abnormal proliferation of mast cells in 1 or more organs. In most patients, a mutation is… Expand Background Histamine is one of the most common chemical mediators causing pruritus, and H1 receptor antagonists have been used… Expand Histamine (0.004–2 μM) induced a concentration‐dependent shape change of human eosinophils, but not of neutrophils or basophils… Expand Using a genomics-based reverse pharmacological approach for screening orphan G-protein coupled receptors, we have identified and… Expand Background: Although there is increasing evidence of the importance of cysteinyl leukotrienes (LT) as mediators of aspirin… Expand A new histamine receptor, HH4R, was cloned from human leukocyte cDNA. The deduced amino acid sequence showed about 40% identity… Expand It is generally accepted that the early asthmatic response to inhaled allergen is a result of IgE‐mediated mast cell activation… Expand AL-4943A (Olopatadine) is a new antihistaminic and anti-allergic drug. It was tested for its ability to compete for [3H… Expand [3H](R)alpha-methylhistamine, a selective histamine H3-receptor ligand, was used to perform binding studies with membranes and… Expand