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Methylhistamines

Known as: Methylhistamines [Chemical/Ingredient], methyl histamine, methylhistamine 
Histamine substituted in any position with one or more methyl groups. Many of these are agonists for the H1, H2, or both histamine receptors.
National Institutes of Health

Related topics

Related topics

21 relations

Narrower (13)

2-amino-5-methylhistamine2-methylhistamine3-methylhistamine4-methylhistamine
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Broader (1)

Histamine
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
GSK189254, a Novel H3 Receptor Antagonist That Binds to Histamine H3 Receptors in Alzheimer's Disease Brain and Improves Cognitive Performance in Preclinical Models
6-[(3-Cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methyl-3-pyridinecarboxamide hydrochloride (GSK189254) is a novel… Expand
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Highly Cited
2006
Highly Cited
2006
Imatinib mesylate in the treatment of systemic mastocytosis
Mastocytosis is characterized by the abnormal proliferation of mast cells in 1 or more organs. In most patients, a mutation is… Expand
Highly Cited
2004
Highly Cited
2004
Pruritus‐associated response mediated by cutaneous histamine H3 receptors
Background  Histamine is one of the most common chemical mediators causing pruritus, and H1 receptor antagonists have been used… Expand
Highly Cited
2003
Highly Cited
2003
Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor
Histamine (0.004–2 μM) induced a concentration‐dependent shape change of human eosinophils, but not of neutrophils or basophils… Expand
Review
2001
Review
2001
Cloning, expression, and pharmacological characterization of a novel human histamine receptor.
Using a genomics-based reverse pharmacological approach for screening orphan G-protein coupled receptors, we have identified and… Expand
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Highly Cited
2001
Highly Cited
2001
Possible involvement of mast‐cell activation in aspirin provocation of aspirin‐induced asthma
Background: Although there is increasing evidence of the importance of cysteinyl leukotrienes (LT) as mediators of aspirin… Expand
Highly Cited
2000
Highly Cited
2000
Molecular cloning and characterization of a new human histamine receptor, HH4R.
A new histamine receptor, HH4R, was cloned from human leukocyte cDNA. The deduced amino acid sequence showed about 40% identity… Expand
Highly Cited
1998
Highly Cited
1998
Urinary excretion of inflammatory mediators during allergen‐induced early and late phase asthmatic reactions
It is generally accepted that the early asthmatic response to inhaled allergen is a result of IgE‐mediated mast cell activation… Expand
Highly Cited
1996
Highly Cited
1996
Olopatadine (AL-4943A): ligand binding and functional studies on a novel, long acting H1-selective histamine antagonist and anti-allergic agent for use in allergic conjunctivitis.
AL-4943A (Olopatadine) is a new antihistaminic and anti-allergic drug. It was tested for its ability to compete for [3H… Expand
Highly Cited
1993
Highly Cited
1993
A detailed autoradiographic mapping of histamine H3 receptors in rat brain areas
[3H](R)alpha-methylhistamine, a selective histamine H3-receptor ligand, was used to perform binding studies with membranes and… Expand
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