Metastatic Prostate Carcinoma

Known as: cancer metastatic prostatic, metastatic prostatic cancer, Prostate Cancer Metastatic 
A carcinoma that arises from the prostate gland and has spread to other anatomic sites.
National Institutes of Health

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Docetaxel-Prednisone RegimenEZH2 geneEZH2 wt AlleleEpithelial Cells
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Papers overview

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Highly Cited
2015
Highly Cited
2015
The Evolutionary History of Lethal Metastatic Prostate Cancer
Cancers emerge from an ongoing Darwinian evolutionary process, often leading to multiple competing subclones within a single… (More)
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Highly Cited
2014
Highly Cited
2014
Enzalutamide in metastatic prostate cancer before chemotherapy.
Enzalutamide is an oral androgen-receptor inhibitor that prolongs survival in men with metastatic castration-resistant prostate… (More)
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Highly Cited
2013
Highly Cited
2013
Alpha emitter radium-223 and survival in metastatic prostate cancer.
BACKGROUND Radium-223 dichloride (radium-223), an alpha emitter, selectively targets bone metastases with alpha particles. We… (More)
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Highly Cited
2010
Highly Cited
2010
An oncogene–tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB
Metastasis is responsible for the majority of prostate cancer–related deaths; however, little is known about the molecular… (More)
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Highly Cited
2004
Highly Cited
2004
Long-term efficacy of zoledronic acid for the prevention of skeletal complications in patients with metastatic hormone-refractory prostate cancer.
In a placebo-controlled randomized clinical trial, zoledronic acid (4 mg via a 15-minute infusion every 3 weeks for 15 months… (More)
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Highly Cited
2003
Highly Cited
2003
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer.
The murine Pten prostate cancer model described in this study recapitulates the disease progression seen in humans: initiation of… (More)
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Highly Cited
2002
Highly Cited
2002
A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma.
BACKGROUND Bone metastases are a common cause of morbidity in patients with prostate carcinoma. We studied the effect of a new… (More)
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Highly Cited
2002
Highly Cited
2002
The polycomb group protein EZH2 is involved in progression of prostate cancer
Prostate cancer is a leading cause of cancer-related death in males and is second only to lung cancer. Although effective… (More)
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Highly Cited
1998
Highly Cited
1998
Interfocal heterogeneity of PTEN/MMAC1 gene alterations in multiple metastatic prostate cancer tissues.
The long arm of chromosome 10 is frequently affected by allelic loss in prostate cancer. PTEN/MMAC1, a candidate tumor suppressor… (More)
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Highly Cited
1995
Highly Cited
1995
Identification of endothelin–1 in the pathophysiology of metastatic adenocarcinoma of the prostate
Prostate cancer is the second most common cause of death from cancer in U.S. men, and advanced, hormone–refractory disease is… (More)
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