FAQ

Metabotropic Glutamate Receptor 7, human

Known as: Metabotropic Glutamate Receptor 7, mGluR7 
Metabotropic glutamate receptor 7 (915 aa, ~102 kDa) is encoded by the human GRM7 gene. This protein is involved in ligand-mediated signaling.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2016
02419952016

Related topics

Related topics

15 relations
G Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingGRM7 geneIntegral Membrane Proteins
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Broader (1)

metabotropic glutamate receptor 7

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Metabotropic Glutamate Receptor 7, human
Plasma membrane
Signal Transduction
Synapses
Synaptic Transmission
Receptors, Cell Surface

Papers overview

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2015
2015
Constitutive activity of metabotropic glutamate receptor 7
Metabotropic glutamate receptors (mGluRs) are class C G protein coupled receptors with widespread central nervous system… (More)
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2012
2012
The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling.
Currently prescribed antidepressants affect the reuptake and/or metabolism of biogenic amines. Unfortunately for patients, these… (More)
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2010
2010
Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate receptor 7.
Phenotypic studies of mice lacking metabotropic glutamate receptor subtype 7 (mGluR7) suggest that antagonists of this receptor… (More)
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2009
2009
Metabotropic Glutamate Receptor 7 Modulates the Rewarding Effects of Cocaine in Rats: Involvement of a Ventral Pallidal GABAergic Mechanism
The metabotropic glutamate receptor 7 (mGluR7) has received much attention as a potential target for the treatment of epilepsy… (More)
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2008
2008
Effects of lead exposure on hippocampal metabotropic glutamate receptor subtype 3 and 7 in developmental rats
A complete explanation of the mechanisms by which Pb2+ exerts toxic effects on developmental central nervous system remains… (More)
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2007
2007
Distribution of group-III metabotropic glutamate receptors in the retina.
In the brain and the retina metabotropic glutamate receptors (mGluRs) modulate synaptic transmission; in particular, L-2-amino-4… (More)
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Highly Cited
2005
Highly Cited
2005
A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo.
Metabotropic glutamate receptor (mGluR) subtypes (mGluR1 to mGluR8) act as important pre- and postsynaptic regulators of… (More)
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1999
1999
A relationship between protein kinase C phosphorylation and calmodulin binding to the metabotropic glutamate receptor subtype 7.
Metabotropic glutamate receptor subtype 7 (mGluR7) is coupled to the inhibitory cyclic AMP cascade and is selectively activated… (More)
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1999
1999
mGluR7-like metabotropic glutamate receptors inhibit NMDA-mediated excitotoxicity in cultured mouse cerebellar granule neurons.
Glutamate-induced glutamate release may be involved in the delayed neuronal death induced by N-methyl-D-aspartate (NMDA). In… (More)
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1995
1995
Distribution of metabotropic glutamate receptor 7 messenger RNA in the developing and adult rat brain.
The large number of metabotropic glutamate receptor subtypes suggests diverse roles in brain function, although specific… (More)
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