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Medical Castration

Refers to the use of drugs to suppress the function of the ovaries or testicles.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
Androgen receptor functions in castration-resistant prostate cancer and mechanisms of resistance to new agents targeting the androgen axis
The metabolic functions of androgen receptor (AR) in normal prostate are circumvented in prostate cancer (PCa) to drive tumor… 
Highly Cited
2008
Highly Cited
2008
Alternative nonsteroidal antiandrogen therapy for advanced prostate cancer that relapsed after initial maximum androgen blockade.
Highly Cited
2007
Highly Cited
2007
Redefining clinically significant castration levels in patients with prostate cancer receiving continuous androgen deprivation therapy.
Highly Cited
2006
Highly Cited
2006
Persistent intraprostatic androgen concentrations after medical castration in healthy men.
CONTEXT The impact of serum androgen manipulation on prostate tissue hormone levels in normal men is unknown. Studies of men with… 
Highly Cited
2003
Highly Cited
2003
Effects of medical or surgical castration on erectile function in an animal model.
The goal of this study was to investigate the effects of medical castration (luteinizing hormone-receptor hormone [LH-RH] agonist… 
Highly Cited
2003
Highly Cited
2003
Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.
Most prostate cancers (PCs) become resistant to combined androgen blockade therapy with surgical or medical castration and… 
Highly Cited
2002
Highly Cited
2002
A phase 3, multicenter, open label, randomized study of abarelix versus leuprolide plus daily antiandrogen in men with prostate cancer.
Highly Cited
2001
Highly Cited
2001
A phase 3, multicenter, open-label, randomized study of abarelix versus leuprolide acetate in men with prostate cancer.
Review
2000
Review
2000
Complete androgen blockade for prostate cancer: what went wrong?
Highly Cited
1998
Highly Cited
1998
A Randomised Comparison of ‘Casodex’TM (Bicalutamide) 150 mg Monotherapy versus Castration in the Treatment of Metastatic and Locally Advanced Prostate Cancer
Objectives: To evaluate the efficacy and tolerability of ‘Casodex’TM monotherapy (150 mg daily) for metastatic and locally… 
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