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Age trends in the level of serum testosterone and other hormones in middle-aged men: longitudinal results from the Massachusetts male aging study.
TLDR
The paradoxical finding that longitudinal age trends were steeper than cross-sectional trends suggests that incident poor health may accelerate the age-related decline in androgen levels. Expand
Bone mineral content of amenorrheic and eumenorrheic athletes.
TLDR
It is concluded that the amenorrhea that is observed in female athletes may be accompanied by a decrease in mineral density of the lumbar vertebrae. Expand
Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction.
TLDR
It is concluded that inhibin B is a unique testicular product that is not detectable in the sera of orchidectomized men, is responsive to FSH stimulation, and has a reciprocal relationship with serum FSH levels in men with various forms of testicular disease. Expand
Exogenous testosterone or testosterone with finasteride increases bone mineral density in older men with low serum testosterone.
TLDR
T therapy in older men with low serum testosterone levels increases vertebral and hip BMD over 36 months, both when administered alone and when combined with F, and suggests that dihydrotestosterone is not essential for the beneficial effects of T on BMD in men. Expand
Intraprostatic androgens and androgen-regulated gene expression persist after testosterone suppression: therapeutic implications for castration-resistant prostate cancer.
TLDR
Optimal clinical efficacy will require testing of novel approaches targeting complete suppression of systemic and intracrine contributions to the prostatic androgen microenvironment. Expand
Inhibin-B: a likely candidate for the physiologically important form of inhibin in men.
TLDR
The results strongly suggest that the physiologically important form of inhibin in men is inhibin B, which has a critical effect on FSH release. Expand
Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens.
TLDR
The sites, developmental pattern, and hormonal control of androgen receptors (AR) in the rat testis are assessed and immunohistochemically detectable AR expression occurs predominantly in stages II-VII of the spermatogenic cycle, with highest levels at stage VII. Expand
Combined administration of levonorgestrel and testosterone induces more rapid and effective suppression of spermatogenesis than testosterone alone: a promising male contraceptive approach.
TLDR
It is concluded that combination hormonal therapy with T plus a progestogen might offer a reversible male contraceptive approach with a more rapid onset of action and more reliable induction of both azoospermia and severe oligOSpermia than T alone. Expand
Low sex hormone-binding globulin, total testosterone, and symptomatic androgen deficiency are associated with development of the metabolic syndrome in nonobese men.
TLDR
Low serum SHBG, low total testosterone, and clinical AD are associated with increased risk of developing MetS over time, particularly in nonoverweight, middle-aged men (BMI, <25). Expand
Reproductive aging: accelerated ovarian follicular development associated with a monotropic follicle-stimulating hormone rise in normal older women.
TLDR
It is concluded that older reproductive age women have accelerated development of a dominant follicle in the presence of the monotropic FSH rise, manifested as a shortened follicular phase and elevated follicularphase E. Expand
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