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Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.
TLDR
The presented expert voting results can be used for support in areas of management of men with APC where there is no high-level evidence, but individualised treatment decisions should as always be based on all of the data available. Expand
Tumor-associated zinc finger mutations in the CTCF transcription factor selectively alter tts DNA-binding specificity.
CTCF is a widely expressed 11-zinc finger (ZF) transcription factor that is involved in different aspects of gene regulation including promoter activation or repression, hormone-responsive geneExpand
Neuroendocrine differentiation in the progression of prostate cancer
TLDR
In metastatic PCa, pretreatment serum CGA levels can be a predictor for progression and survival after endocrine therapy, and it is recommended to measure longitudinal change in serum C GA. Expand
Altered methylation of multiple genes in carcinogenesis of the prostate
TLDR
The findings suggest that methylation of cancer‐related genes may be involved in carcinogenesis of the prostate. Expand
Genetic polymorphisms of hormone-related genes and prostate cancer risk in the Japanese population.
TLDR
This pilot study showed that CYP1B1 and PR polymorphisms, alone or in combination, might be associated with prostate cancer risk and might have potential as a tool for identifying high-risk individuals. Expand
Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
TLDR
The results of genetic analyses indicate that mutations in MSR1 may be associated with risk of prostate cancer in men of both African American and European descent and show that MSR 1 may be important in susceptibility to prostate cancer. Expand
Epigenetic Regulation of Androgen Receptor Gene Expression in Human Prostate Cancers
TLDR
The results suggest that epigenetic regulations including CpG methylation and histone acetylation may play important roles in the regulation of the AR. Expand
Loss of PTEN Is Associated with Aggressive Behavior in ERG-Positive Prostate Cancer
TLDR
A similar frequency of ERG positivity from early to late stage of the disease suggests lack of selection of ERg expression during disease progression, and the finding of consistent genetic alterations in different metastases suggests that the major genetic alterations take place in the primary tumor. Expand
Pretreatment serum testosterone level as a predictive factor of pathological stage in localized prostate cancer patients treated with radical prostatectomy.
TLDR
A lower pretreatment T level appears to be predictive of extraprostatic disease in patients with localized prostate cancer, and pathological Gleason score, pretreatment serum T level and pretreatment PSA were significant predictors of extraProstatic disease. Expand
A randomized trial comparing radical prostatectomy plus endocrine therapy versus external beam radiotherapy plus endocrine therapy for locally advanced prostate cancer: results at median follow-up of
TLDR
For the treatment of patients with locally advanced prostate cancer, when combined with endocrine therapy, either radical prostatectomy or external beam radiotherapy demonstrated favorable long-term outcomes. Expand
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