FAQ

Mastocytosis

Known as: cell disorders mast, cell diseases mast, Mast cell disease 
A clonal myeloproliferative neoplasm characterized by the proliferation and accumulation of neoplastic mast cells in one or multiple organs or organ… (More)

Topic mentions per year

Topic mentions per year

1950-2017
05010015019502016

Related topics

Related topics

24 relations
Blood supply aspectsBone MarrowBone marrow stem cellCromolyn
(More)

Narrower (3)

Mastocytic enterocolitisMastocytosis, Diffuse CutaneousUrticaria Pigmentosa

Broader (1)

manifestations of immunopathology

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Mastocytosis
cancer cell
Bone Marrow
radiotherapeutic
mast cell
prevention & control

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Cutaneous manifestations in patients with mastocytosis: Consensus report of the European Competence Network on Mastocytosis; the American Academy of Allergy, Asthma & Immunology; and the European…
Cutaneous lesions in patients with mastocytosis are highly heterogeneous and encompass localized and disseminated forms. Although… (More)
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Systemic mastocytosis in 342 consecutive adults: survival studies and prognostic factors.
Clinical phenotype in systemic mastocytosis (SM) is markedly variable, which complicates prognostication and decision making… (More)
  • table 1
  • table 2
  • table 3
  • table 4
  • table 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
A novel form of mastocytosis associated with a transmembrane c-kit mutation and response to imatinib.
Mutational analysis of the c-kit gene in a patient with a previously undescribed variant of mast cell disease revealed a germline… (More)
Is this relevant?
Highly Cited
2003
Highly Cited
2003
CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy.
Imatinib mesylate is effective in the treatment of hematologic malignancies that are characterized by either abl- or PDGFR beta… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
Is this relevant?
Highly Cited
2002
Highly Cited
2002
The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild…
Mutations of c-KIT causing spontaneous activation of the KIT receptor kinase are associated with sporadic adult human… (More)
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2000
Highly Cited
2000
IL-9-deficient mice establish fundamental roles for IL-9 in pulmonary mastocytosis and goblet cell hyperplasia but not T cell development.
Interleukin-9 is a cytokine produced by Th2 cells and is a candidate gene for asthma and atopy. We have generated IL-9-deficient… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis.
Human mastocytosis is characterized by increased mast cells. It usually occurs as a sporadic disease that is often transient and… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Somatic c-KIT activating mutation in urticaria pigmentosa and aggressive mastocytosis: establishment of clonality in a human mast cell neoplasm
Mastocytosis Is characterized by accumulations of mast cells in various organs1. Most cases are indolent and confined to the skin… (More)
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder.
Both stem cells and mast cells express c-kit and proliferate after exposure to c-kit ligand. Mutations in c-kit may enhance or… (More)
Is this relevant?
Highly Cited
1987
Highly Cited
1987
Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis.
Better methods are needed to assess mast-cell activation in vivo and to distinguish the activation of mast cells from that of… (More)
Is this relevant?