• Publications
  • Influence
Mixed cryoglobulinemia: clinical aspects and long-term follow-up of 40 patients.
The clinical course of 40 patients with significant quantities of mixed cryoglobulins, but without lymphoproliferative, collagen-vascular or chronic infectious diseases, is presented. These casesExpand
  • 701
  • 19
Repurposing diflunisal for familial amyloid polyneuropathy: a randomized clinical trial.
IMPORTANCE Familial amyloid polyneuropathy, a lethal genetic disease caused by aggregation of variant transthyretin, induces progressive peripheral nerve deficits and disability. Diflunisal, aExpand
  • 377
  • 9
  • PDF
Evaluation of cryoglobulins.
Cryoglobulins are immunoglobulins that precipitate as serum is cooled below core body temperatures. A cryoglobulin screen is the observation of a serum specimen collected and separated while warm forExpand
  • 101
  • 5
  • PDF
In Vitro Evidence That β‐Amyloid Peptide 1–40 Diffuses Across the Blood–Brain Barrier and Affects Its Permeability
Beta amyloid peptides are major insoluble constituents of amyloid fibrils in senile plaques and cerebrovascular deposits, both characteristic of Alzheimer disease (AD). Low concentrations of solubleExpand
  • 66
  • 5
Isolation and Partial Characterization of Neurofibrillary Tangles and Amyloid Plaque Core in Alzheimer's Disease: Immunohistological Studies
Fractions enriched in neurofibrillary tangles (NFT) and amyloid fibrils were isolated from the cerebral cortex of three cases of senile dementia of the Alzheimer type. Distilled water suspensions ofExpand
  • 124
  • 4
  • PDF
Fate of Cerebrospinal Fluid‐Borne Amyloid β‐Peptide: Rapid Clearance into Blood and Appreciable Accumulation by Cerebral Arteries
Abstract: In Alzheimer's disease, the neuritic or senile amyloid plaques in hippocampus and association cortex, the diffuse plaques in brain areas such as the cerebellum and sensorimotor cortex, andExpand
  • 224
  • 4
Association between hepatitis B virus and essential mixed cryoglobulinemia.
In view of a high frequency of liver involvement in patients with essential mixed cryoglubulinemia, we looked for evidence for hepatitis B virus infection in 25 serum specimens and 19Expand
  • 360
  • 3
Beta-2 microglobulin is an amyloidogenic protein in man.
Curvilinear fibrils with the tinctorial properties of amyloid were isolated from a patient with bone and joint involvement complicating chronic dialysis for renal disease. Subunit fractions of 24,000Expand
  • 231
  • 3
  • PDF
In vitro formation of amyloid fibrils from two synthetic peptides of different lengths homologous to Alzheimer's disease beta-protein.
Two synthetic peptides corresponding to the reported 28-residue sequence of Alzheimer's Disease beta-protein (SP28) and to residues 12-28 (SP17) were used to form fibrils in vitro. Synthetic fibrilsExpand
  • 203
  • 3