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Macrophage-1 Antigen

Known as: Integrin Alpha-M/Beta-2, Mac 1, Mac-1 Antigen 
An adhesion-promoting leukocyte surface membrane heterodimer. The alpha subunit consists of the CD11b ANTIGEN and the beta subunit the CD18 ANTIGEN… 
National Institutes of Health

Related topics

Related topics

17 relations
CD11b AntigensCD18 AntigensCell AdhesionCell Adhesion Molecules

Broader (1)

Receptors, Leukocyte-Adhesion

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Complement-mediated mechanisms in anti-GD2 monoclonal antibody therapy of murine metastatic cancer.
The role of complement in antibody therapy of cancer is in general poorly understood. We used the EL4 syngeneic mouse model of… 
Highly Cited
2003
Highly Cited
2003
Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migration.
Previous studies demonstrated that integrin alpha(M)beta(2) (CD11b/18, Mac-1) forms a physical complex with the urokinase-type… 
Highly Cited
1996
Highly Cited
1996
A comparison of long-term repopulating hematopoietic stem cells in fetal liver and adult bone marrow from the mouse.
Previous studies have shown that stem cells able to competitively reconstitute the hematopoietic system of lethally irradiated… 
Highly Cited
1996
Highly Cited
1996
Urokinase-type plasminogen activator receptor reversibly dissociates from complement receptor type 3 (alpha M beta 2' CD11b/CD18) during neutrophil polarization.
Previous studies have shown that the leukocyte integrin CR3 (CD11b/CD18) is physically associated with the urokinase-type… 
Highly Cited
1995
Highly Cited
1995
Monocyte migration to arthritis in the rat utilizes both CD11/CD18 and very late activation antigen 4 integrin mechanisms
In human and experimental models of arthritis, blood monocytes migrate into the inflamed synovium and joint space. The mechanisms… 
Highly Cited
1992
Highly Cited
1992
Analysis of cytokine mRNA levels in interleukin‐4‐transgenic mice by quantitative polymerase chain reaction
Interleukin (IL)‐4‐transgenic mice were used as a model system to study the consequences of low levels of IL‐4 expression for the… 
Highly Cited
1992
Highly Cited
1992
The contribution of LFA-1 (CD11a/CD18) and MAC-1 (CD11b/CD18) to the in vivo migration of polymorphonuclear leucocytes to inflammatory reactions in the rat.
Recently the critical requirement for the CD18 family of adhesion molecules on leucocytes for their adhesion and migration to… 
Highly Cited
1987
Highly Cited
1987
In vivo inhibition of neutrophil function in the rabbit using monoclonal antibody to CD18.
The CD11b/CD18 membrane antigen complex has been shown to be essential for normal neutrophil function in vitro, and patients… 
Highly Cited
1986
Highly Cited
1986
LFA-1 immunodeficiency disease. Definition of the genetic defect and chromosomal mapping of alpha and beta subunits of the lymphocyte function-associated antigen 1 (LFA-1) by complementation in…
Lymphocyte function associated antigen 1 (LFA-1) is a leukocyte cell adhesion protein. We have studied a novel human… 
Review
1982
Review
1982
LFA‐1 and Lyt‐2,3, Molecules Associated with T Lymphocyte‐Mediated Killing; and Mac‐1, an LFA‐1 Homologue Associated with Complement Receptor Function 1
Killer cells are an important component in the immune response to cells with altered or foreign cell surface antigens. Antigen… 
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