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MYOC gene

Known as: juvenile-onset open-angle glaucoma 1, TIGR, MYOCILIN 
National Institutes of Health

Related topics

Related topics

3 relations
GLAUCOMA 1, OPEN ANGLE, AMYOC protein, humantrabecular meshwork-induced glucocorticoid response protein

Papers overview

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Highly Cited
2009
Highly Cited
2009
Correction of the disease phenotype of myocilin-causing glaucoma by a natural osmolyte.
PURPOSE To characterize a novel Asp384Asn (D384N) mutant myocilin (MYOC) that causes juvenile-onset open-angle glaucoma (JOAG… 
2006
2006
Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure.
PURPOSE To characterize the changes in retinal gene expression induced by elevated intraocular pressure (IOP) in a hereditary… 
2006
2006
Perfusion of his-tagged eukaryotic myocilin increases outflow resistance in human anterior segments in the presence of aqueous humor.
PURPOSE A previous study by the authors has shown that recombinant myocilin purified from a prokaryotic expression system… 
Highly Cited
2005
Highly Cited
2005
Myocilin binding to Hep II domain of fibronectin inhibits cell spreading and incorporation of paxillin into focal adhesions.
Highly Cited
2004
Highly Cited
2004
Overexpression of myocilin in cultured human trabecular meshwork cells.
2003
2003
Secreted glycoprotein myocilin is a component of the myelin sheath in peripheral nerves
The structure of the myelin sheath in peripheral nerves requires the expression of a specific set of proteins. In the present… 
Highly Cited
2002
Highly Cited
2002
Myocilin is associated with mitochondria in human trabecular meshwork cells
The trabecular meshwork (TM) is a specialized tissue located at the chamber angle of the eye next to the cornea. This tissue is… 
2000
2000
Localization of myocilin to the golgi apparatus in Schlemm's canal cells.
PURPOSE Biochemical and genetic evidence suggests that overexpression of or mutations in myocilin within the cells of the aqueous… 
Highly Cited
2000
Highly Cited
2000
TIGR/myocilin in human aqueous humor.
Highly Cited
1998
Highly Cited
1998
Genomic organization of the human myocilin gene (MYOC) responsible for primary open angle glaucoma (GLC1A).
Myocilin is a newly found cytoskeletal protein involved in the morphogenesis of the basal body, a major microtubule organizing… 
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