Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure.

@article{Naskar2006RetinalGP,
  title={Retinal gene profiling in a hereditary rodent model of elevated intraocular pressure.},
  author={Rita Naskar and Solon Thanos},
  journal={Molecular vision},
  year={2006},
  volume={12},
  pages={1199-210}
}
PURPOSE To characterize the changes in retinal gene expression induced by elevated intraocular pressure (IOP) in a hereditary rodent model. METHODS A rat model derived from the RCS-rdy- strain develops IOP elevation spontaneously without experimental manipulation. Retinal gene expression after IOP elevation was compared with age-matched RCS-rdy- retinas having normal IOP levels The MWG Rat 10k array, which comprises 9715 rat genes spotted onto one array was used. Quantitative real-time PCR… CONTINUE READING