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MYCN wt Allele

Known as: NMYC, v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) wt Allele, MODED 
Human MYCN wild-type allele is located in the vicinity of 2p24.1 and is approximately 6 kb in length. This allele, which encodes N-myc proto-oncogene… 
National Institutes of Health

Related topics

Related topics

7 relations
2p24.1Homo sapiensNMYC Gene Amplification dysfunctionNeuroblastoma

Broader (1)

MYCN gene

Papers overview

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Highly Cited
1998
Highly Cited
1998
Stratification of treatment of stage 4 neuroblastoma patients based on N-myc amplification status. Study Group of Japan for Treatment of Advanced Neuroblastoma, Tokyo, Japan.
BACKGROUND It has been shown that children aged more than 12 months with stage 3 and 4 neuroblastoma with N-myc amplification do… 
1996
1996
The DDX1 gene maps within 400 kbp 5′ to MYCN and is frequently coamplified in human neuroblastoma
Human neuroblastoma cells frequently show amplification of the oncogene MYCN, which maps to 2p24. Previous studies have localized… 
1995
1995
N-myc protein expression in human breast carcinoma: prognostic implications.
The overexpression of N-myc gene and its protein products has been thought to be limited to cases of neuroblastoma… 
Highly Cited
1994
Highly Cited
1994
Coactivation of the MDR1 and MYCN genes in human neuroblastoma cells during the metastatic process in the nude mouse.
In metastatic human neuroblastoma, MYCN amplification and MDR1 overexpression are frequently observed. No in vivo model is yet… 
Highly Cited
1994
Highly Cited
1994
The biological effects of antisense N-myc expression in human neuroblastoma.
Although N-myc amplification and overexpression are believed to play an important role in determining the clinical behavior of… 
Highly Cited
1990
Highly Cited
1990
N-myc down regulates neural cell adhesion molecule expression in rat neuroblastoma
In human neuroblastoma, amplification of the N-myc oncogene is correlated with increased metastatic ability. We recently showed… 
Highly Cited
1990
Highly Cited
1990
Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line.
The N-myc gene is transiently expressed during normal embryonic development and abnormally expressed in several tumors of… 
Highly Cited
1987
Highly Cited
1987
N-myc oncogene amplification and prognostic factors of neuroblastoma in children.
Review
1985
Review
1985
Expression of N-myc in teratocarcinoma stem cells and mouse embryos
The N-myc gene, which is distantly related to the proto-oncogene c-myc, was first detected as an amplified sequence in human… 
Highly Cited
1985
Highly Cited
1985
N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas.
Molecular characterization of two human neuroblastoma cell lines has revealed that both contain multiple homogeneously staining… 
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