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MYCN wt Allele
Known as:
NMYC
, v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) wt Allele
, MODED
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Human MYCN wild-type allele is located in the vicinity of 2p24.1 and is approximately 6 kb in length. This allele, which encodes N-myc proto-oncogene…
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National Institutes of Health
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Related topics
Related topics
7 relations
2p24.1
Homo sapiens
NMYC Gene Amplification dysfunction
Neuroblastoma
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Broader (1)
MYCN gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Stratification of treatment of stage 4 neuroblastoma patients based on N-myc amplification status. Study Group of Japan for Treatment of Advanced Neuroblastoma, Tokyo, Japan.
M. Kaneko
,
H. Nishihira
,
+7 authors
Y. Tsuchida
Medical and Pediatric Oncology
1998
Corpus ID: 28255229
BACKGROUND It has been shown that children aged more than 12 months with stage 3 and 4 neuroblastoma with N-myc amplification do…
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1996
1996
The DDX1 gene maps within 400 kbp 5′ to MYCN and is frequently coamplified in human neuroblastoma
L. Amler
,
J. Schürmann
,
M. Schwab
Genes, Chromosomes and Cancer
1996
Corpus ID: 25252148
Human neuroblastoma cells frequently show amplification of the oncogene MYCN, which maps to 2p24. Previous studies have localized…
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1995
1995
N-myc protein expression in human breast carcinoma: prognostic implications.
Y. Mizukami
,
A. Nonomura
,
+4 authors
T. Ishizaki
Anticancer Research
1995
Corpus ID: 13245087
The overexpression of N-myc gene and its protein products has been thought to be limited to cases of neuroblastoma…
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Highly Cited
1994
Highly Cited
1994
Coactivation of the MDR1 and MYCN genes in human neuroblastoma cells during the metastatic process in the nude mouse.
E. Ferrandis
,
J. Silva
,
G. Riou
,
I. Bénard
Cancer Research
1994
Corpus ID: 37326337
In metastatic human neuroblastoma, MYCN amplification and MDR1 overexpression are frequently observed. No in vivo model is yet…
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Highly Cited
1994
Highly Cited
1994
The biological effects of antisense N-myc expression in human neuroblastoma.
Mary Lou Schmidt
,
H. Salwen
,
C. Manohar
,
N. Ikegaki
,
Susan L. Cohn
Cell growth & differentiation : the molecular…
1994
Corpus ID: 18412804
Although N-myc amplification and overexpression are believed to play an important role in determining the clinical behavior of…
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Highly Cited
1990
Highly Cited
1990
N-myc down regulates neural cell adhesion molecule expression in rat neuroblastoma
R. Akeson
,
R. Bernards
Molecular and Cellular Biology
1990
Corpus ID: 8089013
In human neuroblastoma, amplification of the N-myc oncogene is correlated with increased metastatic ability. We recently showed…
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Highly Cited
1990
Highly Cited
1990
Antisense inhibition of single copy N-myc expression results in decreased cell growth without reduction of c-myc protein in a neuroepithelioma cell line.
Angelo Rosolen
,
L. Whitesell
,
N. Ikegaki
,
R. Kennett
,
L. Neckers
Cancer Research
1990
Corpus ID: 46137598
The N-myc gene is transiently expressed during normal embryonic development and abnormally expressed in several tumors of…
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Highly Cited
1987
Highly Cited
1987
N-myc oncogene amplification and prognostic factors of neuroblastoma in children.
A. Nakagawara
,
K. Ikeda
,
T. Tsuda
,
Kengi Higashi
Journal of Pediatric Surgery
1987
Corpus ID: 36746790
Review
1985
Review
1985
Expression of N-myc in teratocarcinoma stem cells and mouse embryos
A. Jakobovits
,
M. Schwab
,
J. Michael Bishop
,
Gail R. Martin
Nature
1985
Corpus ID: 4319555
The N-myc gene, which is distantly related to the proto-oncogene c-myc, was first detected as an amplified sequence in human…
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Highly Cited
1985
Highly Cited
1985
N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas.
B. Emanuel
,
G. Balaban
,
+4 authors
M. Glick
Proceedings of the National Academy of Sciences…
1985
Corpus ID: 23860076
Molecular characterization of two human neuroblastoma cell lines has revealed that both contain multiple homogeneously staining…
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