MYCN wt Allele

Known as: NMYC, v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) wt Allele, MODED 
Human MYCN wild-type allele is located in the vicinity of 2p24.1 and is approximately 6 kb in length. This allele, which encodes N-myc proto-oncogene… (More)
National Institutes of Health

Related topics

Related topics

7 relations
2p24.1Homo sapiensNMYC Gene Amplification dysfunctionNeuroblastoma
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Broader (1)

MYCN gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
Pleiotropic role for MYCN in medulloblastoma.
Medulloblastoma (MB) is the most common malignant brain tumor of childhood. Sonic Hedgehog (SHH) signaling drives a minority of… (More)
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Highly Cited
2008
Highly Cited
2008
Distinct transcriptional MYCN/c-MYC activities are associated with spontaneous regression or malignant progression in neuroblastomas
Amplified MYCN oncogene resulting in deregulated MYCN transcriptional activity is observed in 20% of neuroblastomas and… (More)
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Highly Cited
2004
Highly Cited
2004
Natural Killer T Cells Infiltrate Neuroblastomas Expressing the Chemokine CCL2
CD1d-restricted Valpha24-Jalpha18-invariant natural killer T cells (iNKTs) are potentially important in tumor immunity. However… (More)
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Highly Cited
2003
Highly Cited
2003
Transcriptional profiling of the Sonic hedgehog response: a critical role for N-myc in proliferation of neuronal precursors.
Cerebellar granule cells are the most abundant neurons in the brain, and granule cell precursors (GCPs) are a common target of… (More)
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Highly Cited
2002
Highly Cited
2002
MYCC and MYCN oncogene amplification in medulloblastoma. A fluorescence in situ hybridization study on paraffin sections from the Children's Oncology Group.
CONTEXT Brain tumors are the most common solid tumor in childhood, and medulloblastoma is the most common malignant brain tumor… (More)
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Highly Cited
2000
Highly Cited
2000
Biologic factors determine prognosis in infants with stage IV neuroblastoma: A prospective Children's Cancer Group study.
PURPOSE A prospective Children's Cancer Group study, CCG-3881, has been completed to determine if a more accurate prediction of… (More)
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Highly Cited
1999
Highly Cited
1999
Allelic deletion at 11q23 is common in MYCN single copy neuroblastomas
Deletions of the long arm of chromosome 11 (11q) have been noted in primary neuroblastomas, but a comprehensive analysis has not… (More)
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Highly Cited
1997
Highly Cited
1997
Targeted expression of MYCN causes neuroblastoma in transgenic mice.
The proto-oncogene MYCN is often amplified in human neuroblastomas. The assumption that the amplification contributes to… (More)
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Highly Cited
1993
Highly Cited
1993
Association between high levels of expression of the TRK gene and favorable outcome in human neuroblastoma.
BACKGROUND AND METHODS The nerve growth factor receptor is expressed in some neuroblastomas, in which its primary component is… (More)
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Highly Cited
1985
Highly Cited
1985
Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas.
Eighty-nine patients with untreated primary neuroblastomas were studied to determine the relation between the number of copies of… (More)
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