Skip to search formSkip to main contentSkip to account menu

MYCN wt Allele

Known as: NMYC, v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) wt Allele, MODED 
Human MYCN wild-type allele is located in the vicinity of 2p24.1 and is approximately 6 kb in length. This allele, which encodes N-myc proto-oncogene… 
National Institutes of Health

Related topics

Related topics

7 relations
2p24.1Homo sapiensNMYC Gene Amplification dysfunctionNeuroblastoma

Broader (1)

MYCN gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2002
Highly Cited
2002
The impact of surgical radicality on outcome in childhood neuroblastoma.
Highly Cited
1999
Highly Cited
1999
HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts
N-myc gene copy numbers and transcription rates are similar in N (neuroblastic, tumorigenic) and S (non-neuronal, non-tumorigenic… 
Highly Cited
1998
Highly Cited
1998
Stratification of treatment of stage 4 neuroblastoma patients based on N-myc amplification status. Study Group of Japan for Treatment of Advanced Neuroblastoma, Tokyo, Japan.
BACKGROUND It has been shown that children aged more than 12 months with stage 3 and 4 neuroblastoma with N-myc amplification do… 
Highly Cited
1994
Highly Cited
1994
Expression of the multidrug resistance-associated protein (MRP) gene correlates with amplification and overexpression of the N-myc oncogene in childhood neuroblastoma.
The MRP gene (Cole et al., Science (Washington DC), 258: 1650-1654, 1992) encodes a membrane-bound glycoprotein the expression of… 
Highly Cited
1994
Highly Cited
1994
Coactivation of the MDR1 and MYCN genes in human neuroblastoma cells during the metastatic process in the nude mouse.
In metastatic human neuroblastoma, MYCN amplification and MDR1 overexpression are frequently observed. No in vivo model is yet… 
Highly Cited
1994
Highly Cited
1994
The biological effects of antisense N-myc expression in human neuroblastoma.
Although N-myc amplification and overexpression are believed to play an important role in determining the clinical behavior of… 
Highly Cited
1990
Highly Cited
1990
N-myc down regulates neural cell adhesion molecule expression in rat neuroblastoma
In human neuroblastoma, amplification of the N-myc oncogene is correlated with increased metastatic ability. We recently showed… 
Highly Cited
1989
Highly Cited
1989
N-myc amplification and neuronal differentiation in human primitive neuroectodermal tumors of the central nervous system.
Despite the phenotypic similarities between primitive neuroectodermal tumors of the central nervous system, childhood… 
Review
1985
Review
1985
Expression of N-myc in teratocarcinoma stem cells and mouse embryos
The N-myc gene, which is distantly related to the proto-oncogene c-myc, was first detected as an amplified sequence in human… 
Highly Cited
1985
Highly Cited
1985
N-myc amplification in multiple homogeneously staining regions in two human neuroblastomas.
Molecular characterization of two human neuroblastoma cell lines has revealed that both contain multiple homogeneously staining… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)