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MYCN gene

Known as: v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) Gene, Neuroblastoma MYC Oncogene, bHLHe37 
Human Oncogene NMYC is a mutated variant of NMYC Gene (MYC Family), which encodes two nuclear N-MYC Proteins from the same mRNA; both are… 
National Institutes of Health

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Related topics

12 relations
2p24.1Homo sapiensMYCN protein, humanMYCNOS gene

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MYCN wt Allele

Papers overview

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Highly Cited
2007
Highly Cited
2007
Novel noncatalytic role for caspase-8 in promoting SRC-mediated adhesion and Erk signaling in neuroblastoma cells.
Neuroblastomas are extremely aggressive, although heterogeneous, cancers with a poor prognosis upon metastasis. Some evidence has… 
Highly Cited
2003
Highly Cited
2003
c‐Kit is preferentially expressed in MYCN‐amplified neuroblastoma and its effect on cell proliferation is inhibited in vitro by STI‐571
Coexpression for c‐Kit receptor and its ligand stem cell factor (SCF) has been described in neuroblastoma (NB) cell lines and… 
Highly Cited
2002
Highly Cited
2002
Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma.
The MYCN oncogene is amplified in approximately 25% of neuroblastoma tumors and is the most significant negative prognostic… 
Highly Cited
2002
Highly Cited
2002
HuD, a Neuronal-specific RNA-binding Protein, Increases thein Vivo Stability of MYCN RNA*
MYCN amplification and consequent deregulated expression plays a crucial role in determining the clinical behavior of… 
Highly Cited
2001
Highly Cited
2001
Detection of MYCN gene amplification in neuroblastoma by fluorescence in situ hybridization: a pediatric oncology group study.
To assess the utility of fluorescence in situ hybridization (FISH) for analysis of MYCN gene amplification in neuroblastoma, we… 
Highly Cited
1999
Highly Cited
1999
Altered expression of the MYCN oncogene modulates MRP gene expression and response to cytotoxic drugs in neuroblastoma cells
We have recently shown a close correlation between expression of the Multidrug Resistance-associated Protein (MRP) gene and the… 
Highly Cited
1997
Highly Cited
1997
MYCN oncogene amplification in neuroblastoma is associated with worse prognosis, except in stage 4s: the Italian experience with 295 children.
PURPOSE To evaluate the prognostic role of MYCN oncogene amplification in children with neuroblastoma. PATIENTS AND METHODS Of… 
Highly Cited
1997
Highly Cited
1997
MYCN protein expression as a predictor of neuroblastoma prognosis.
About half of nonlocalized neuroblastomas have MYCN gene amplification and usually progress rapidly, but the half without such… 
1997
1997
The prognostic value of MDR1 gene expression in primary untreated neuroblastoma.
Highly Cited
1994
Highly Cited
1994
CD44H expression by human neuroblastoma cells: relation to MYCN amplification and lineage differentiation.
The human CD44 cell surface glycoprotein has been involved in a variety of functions including lymphocyte homing, extracellular… 
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