MYCN gene

Known as: v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) Gene, Neuroblastoma MYC Oncogene, bHLHe37 
Human Oncogene NMYC is a mutated variant of NMYC Gene (MYC Family), which encodes two nuclear N-MYC Proteins from the same mRNA; both are… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1984-2018
05010019842018

Papers overview

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Review
2016
Review
2016
Neuroblastoma, an embryonal tumor arising from neural crest-derived progenitor cells, is the most common solid tumor in childhood… (More)
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Highly Cited
2013
Highly Cited
2013
Bromodomain inhibition comprises a promising therapeutic strategy in cancer, particularly for hematologic malignancies. To date… (More)
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Highly Cited
2012
Highly Cited
2012
Neuroblastoma is a childhood tumour of the peripheral sympathetic nervous system. The pathogenesis has for a long time been quite… (More)
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Highly Cited
2010
Highly Cited
2010
MicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which… (More)
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Highly Cited
2008
Highly Cited
2008
Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma tumors, and both are associated with an… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND The aggressiveness of metastatic neuroblastomas that lack MYCN gene amplification varies with age--they are least… (More)
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Highly Cited
2005
Highly Cited
2005
The MYCN oncogene is the major negative prognostic marker in neuroblastoma with important roles in both the pathogenesis and… (More)
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Highly Cited
2004
Highly Cited
2004
The mechanisms causing persistence of embryonal cells that later give rise to tumors is unknown. One tumorigenic factor in the… (More)
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Highly Cited
2000
Highly Cited
2000
Caspase 8 is a cysteine protease regulated in both a death-receptor-dependent and -independent manner during apoptosis. Here, we… (More)
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Highly Cited
1997
Highly Cited
1997
The proto-oncogene MYCN is often amplified in human neuroblastomas. The assumption that the amplification contributes to… (More)
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