MYCN protein, human

Known as: v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) protein, human, bHLHe37, Class E Basic Helix-Loop-Helix Protein 37 
N-myc proto-oncogene protein (464 aa, ~50 kDa) is encoded by the human MYCN gene. This protein plays a role in the regulation of transcription and… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
UNLABELLED Children and young adults with glioblastoma (GBM) have a median survival rate of only 12 to 15 months, and these GBMs… (More)
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Highly Cited
2012
Highly Cited
2012
Neuroblastoma is a pediatric tumor of the sympathetic nervous system. MYCN (V-myc myelocytomatosis viral-related oncogene… (More)
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Highly Cited
2012
Highly Cited
2012
The ALK(F1174L) mutation is associated with intrinsic and acquired resistance to crizotinib and cosegregates with MYCN in… (More)
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Highly Cited
2010
Highly Cited
2010
Medulloblastoma (MB) is the most common malignant brain tumor of childhood. Sonic Hedgehog (SHH) signaling drives a minority of… (More)
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Highly Cited
2008
Highly Cited
2008
Loss of 1p36 heterozygosity commonly occurs with MYCN amplification in neuroblastoma tumors, and both are associated with an… (More)
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Highly Cited
2006
Highly Cited
2006
Amplification of MYCN occurs commonly in neuroblastoma. We report that phosphatidylinositol 3-kinase (PI3K) inhibition in murine… (More)
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Highly Cited
2005
Highly Cited
2005
The MYCN oncogene is the major negative prognostic marker in neuroblastoma with important roles in both the pathogenesis and… (More)
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Highly Cited
2004
Highly Cited
2004
The mechanisms causing persistence of embryonal cells that later give rise to tumors is unknown. One tumorigenic factor in the… (More)
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Highly Cited
1999
Highly Cited
1999
Amplification of the MYCN gene is found in a large proportion of neuroblastoma and considered as an adverse prognostic factor. To… (More)
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Highly Cited
1997
Highly Cited
1997
The proto-oncogene MYCN is often amplified in human neuroblastomas. The assumption that the amplification contributes to… (More)
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