Expression of N-myc in teratocarcinoma stem cells and mouse embryos

@article{Jakobovits1985ExpressionON,
  title={Expression of N-myc in teratocarcinoma stem cells and mouse embryos},
  author={Aya Beverly Hills Jakobovits and Ed. Manfred Schwab and J. Michael Bishop and Gail Roberts Martin},
  journal={Nature},
  year={1985},
  volume={318},
  pages={188-191}
}
The N-myc gene, which is distantly related to the proto-oncogene c-myc, was first detected as an amplified sequence in human neuroblastoma cell lines and tumours1,2. It has since been revealed that there is up to a 300-fold amplification of N-myc DNA in almost 50% of advanced metastatic human neuroblastomas, whereas amplification is not detected in less advanced tumours that have a better prognosis (ref. 3 and M.S., unpublished data). Although expression of N-myc is detectable in all… CONTINUE READING
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