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MUC16 gene

Known as: mucin 16, cell surface associated, CA125, MUCIN 16 
This gene is involved in both cellular adhesion and the maintenance of mucosal surfaces.
National Institutes of Health

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Immune responseMucin-16

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MUC16 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
A 2-Protein Signature Predicting Clinical Outcome in High-Grade Serous Ovarian Cancer
Objective High-grade serous ovarian cancer (HGSOC) accounts for approximately 70% deaths in ovarian cancer. The overall survival… 
2017
2017
Cancer Antigen 125 (CA125, MUC16) Protein Expression in the Diagnosis and Progression of Pancreatic Ductal Adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive carcinoma, with most patients diagnosed at an advanced stage, with a 5… 
2016
2016
C-terminus of MUC16 activates Wnt signaling pathway through its interaction with β-catenin to promote tumorigenesis and metastasis
MUC16/CA125 has been identified as a prominent cancer biomarker, especially for epithelial ovarian cancers, in clinical test for… 
2015
2015
A novel monoclonal antibody to a defined peptide epitope in MUC16.
The MUC16 mucin is overexpressed and aberrantly glycosylated in ovarian carcinomas. Immunodetection of circulating MUC16 is one… 
Highly Cited
2010
Highly Cited
2010
Novel Monoclonal Antibodies Against the Proximal (Carboxy-Terminal) Portions of MUC16
The CA125 antigen, recognized by the OC125 antibody, is a tissue-specific circulating antigen expressed in ovarian cancer. The… 
2010
2010
Mucin gene expression and mouse middle ear epithelium.
Review
2010
Review
2010
Conflicting Views on the Molecular Structure of the Cancer Antigen CA125/MUC16
CA125 is a tumor antigen used to monitor the progression and regression of epithelial ovarian cancer. Despite the widespread use… 
2009
2009
CA125/MUC16 Is Dispensable for Mouse Development and Reproduction
Cancer antigen 125 (CA125) is a blood biomarker that is routinely used to monitor the progression of human epithelial ovarian… 
2003
2003
[Normal human conjunctival epithelium expresses MUC13, MUC15, MUC16 and MUC17 mucin genes].
PURPOSE The ocular surface epithelia express at least five mucin genes of the total of 17 human mucin genes that have been… 
Highly Cited
1997
Highly Cited
1997
Phase II trial of oral altretamine for relapsed ovarian carcinoma: evaluation of defining response by serum CA125.
PURPOSE A phase II study was performed of oral altretamine in 71 patients with ovarian carcinoma who entered clinical complete… 
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