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MTHFR gene

Known as: methylenetetrahydrofolate reductase gene, 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE, MTHFR 
This gene is involved in folate metabolism and methionine biosynthesis.
National Institutes of Health

Related topics

Related topics

5 relations
5,10-Methylenetetrahydrofolate Reductase (FADH2)Methylenetetrahydrofolate reductase (NADPH)Oxidation-Reductionfolic acid metabolism

Broader (1)

Genes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Gene-nutrient interactions in one-carbon metabolism.
Advances in molecular biology greatly contributed, in the past decades, to a deeper understanding of the role of gene function in… 
Highly Cited
2005
Highly Cited
2005
Late-onset thrombocytic microangiopathy caused by cblC disease: association with a factor H mutation.
BACKGROUND cblC disease is a cause of hemolytic uremic syndrome (HUS), which has been primarily described in neonates and infants… 
Highly Cited
2004
Highly Cited
2004
Association of MTHFR Gene Variants with Autism
Autism is a complex neurodevelopment disorder with numerous possible genetic and environmental influences. We retrospectively… 
Highly Cited
1999
Highly Cited
1999
Methylenetetrahydrofolate Reductase Polymorphism, Folate, and Susceptibility to Preeclampsia
Objectives: To test the hypothesis that the common missense mutation of 5,10-methylenetetrahydrofolate reductase (MTHFR) (677 C… 
Highly Cited
1999
Highly Cited
1999
A common mutation in the methylenetetrahydrofolate reductase gene is a determinant of hyperhomocysteinemia in epileptic patients receiving anticonvulsants.
Highly Cited
1999
Highly Cited
1999
Mortality risk in men is associated with a common mutation in the methylenetetrahydrofolate reductase gene (MTHFR)
An elevated level of homocysteine in plasma is associated with the occurrence of cardiovascular disease. A common ala-to-val… 
Review
1997
Review
1997
The VITA Project: C677T mutation in the methylene‐tetrahydrofolate reductase gene and risk of venous thromboembolism
We evaluated the hypothesis that a common polymorphism of the methylenetetrahydrofolate reductase gene (C677T), which results in… 
Highly Cited
1997
Highly Cited
1997
A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction.
Highly Cited
1997
Highly Cited
1997
Association between plasma total homocysteine and parental history of cardiovascular disease in children with familial hypercholesterolemia.
BACKGROUND Recently, we reported a relation between plasma total homocysteine (tHcy) in children and cardiovascular disease (CVD… 
Highly Cited
1976
Highly Cited
1976
Morphologic Studies in a Patient with Homocystinuria due to 5,10-Methylenetetrahydrofolate Reductase Deficiency
Extract: Biochemical and morphologic studies on a patient with homocystinuria due to a deficiency of 5,10… 
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