MTHFR gene

Known as: methylenetetrahydrofolate reductase gene, 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE, MTHFR 
This gene is involved in folate metabolism and methionine biosynthesis.
National Institutes of Health

Papers overview

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2011
2011
INTRODUCTION Two functional single nucleotide polymorphisms (SNPs) in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene… (More)
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2005
2005
BACKGROUND cblC disease is a cause of hemolytic uremic syndrome (HUS), which has been primarily described in neonates and infants… (More)
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2004
2004
Autism is a complex neurodevelopment disorder with numerous possible genetic and environmental influences. We retrospectively… (More)
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Highly Cited
2003
Highly Cited
2003
AbstractCommon single nucleotide polymorphisms (SNPs; 677C>T and 1298A>C) in the methylenetetrahydrofolate reductase gene (MTHFR… (More)
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Highly Cited
2003
Highly Cited
2003
Folate metabolism is thought to play an important role in carcinogenesis through its involvement in both DNA methylation and… (More)
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Highly Cited
2002
Highly Cited
2002
Evidence is growing that low folate status may be a factor in the aetiology of several cancers, including breast cancer. The… (More)
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Highly Cited
2000
Highly Cited
2000
5-methyltetrahydrofolate is the predominant form of folate in plasma. It may be the preferred substrate for transport via the… (More)
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Highly Cited
1998
Highly Cited
1998
We examined the relationship between a functional polymorphism (667C-->T, ala-->val) of the methylenetetrahydrofolate reductase… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND AND PURPOSE A common polymorphism (T/t) in the gene encoding the methylenetetrahydrofolate reductase (MTHFR) enzyme… (More)
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Highly Cited
1996
Highly Cited
1996
Mild hyperhomocysteinemia is an established risk factor for cardiovascular disease. Genetic aberrations in the cystathionine beta… (More)
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