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Methylenetetrahydrofolate reductase (NADPH)

Known as: Methylenetetrahydrofolate Reductase, Methylene-THF Reductase (NADPH), MTHFR 
A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Moderate hyperhomocysteinemia‐induced low folate status is an independent risk factor for cardiovascular disease, dementia, and… Expand
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Highly Cited
2002
Highly Cited
2002
DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Obstetrical complications such as severe preeclampsia, abruptio placentae, fetal growth retardation, and stillbirth… Expand
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Highly Cited
1998
Highly Cited
1998
Recently, we showed that homozygosity for the common 677(C-->T) mutation in the methylenetetrahydrofolate reductase (MTHFR) gene… Expand
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Highly Cited
1998
Highly Cited
1998
A common mutation in methylenetetrahydrofolate reductase (MTHFR), C677T, results in a thermolabile variant with reduced activity… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND The results of retrospective and prospective case-control studies have clearly established that mild elevations of the… Expand
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate, the major carbon donor in… Expand
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Highly Cited
1995
Highly Cited
1995
Hyperhomocysteinaemia has been identified as a risk factor for cerebrovascular, peripheral vascular and coronary heart disease1–4… Expand
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Highly Cited
1995
Highly Cited
1995
Periconceptional folate supplementation reduces the risk of neural-tube defects. We studied the frequency of the 677C-->T… Expand
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Highly Cited
1994
Highly Cited
1994
Methylenetetrahydrofolate reductase (MTHFR) catalyses the reduction of methylenetetrahydrofolate to methyltetrahydrofolate, a… Expand
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