Methylenetetrahydrofolate reductase (NADPH)

Known as: Methylenetetrahydrofolate Reductase, Methylene-THF Reductase (NADPH), MTHFR 
A flavoprotein amine oxidoreductase that catalyzes the reversible conversion of 5-methyltetrahydrofolate to 5,10-methylenetetrahydrofolate. This… (More)
National Institutes of Health

Papers overview

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Highly Cited
2002
Highly Cited
2002
DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by… (More)
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Highly Cited
2001
Highly Cited
2001
Methylenetetrahydrofolate reductase (MTHFR) catalyzes the conversion of methylenetetrahydrofolate to methyltetrahydrofolate, the… (More)
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Highly Cited
1999
Highly Cited
1999
Elevated plasma homocysteine levels are associated with increased risk for cardiovascular disease and neural tube defects in… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Down syndrome, or trisomy 21, is a complex genetic disease resulting from the presence of 3 copies of chromosome 21… (More)
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Highly Cited
1998
Highly Cited
1998
Recently, we showed that homozygosity for the common 677(C-->T) mutation in the methylenetetrahydrofolate reductase (MTHFR) gene… (More)
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Highly Cited
1998
Highly Cited
1998
A common mutation in methylenetetrahydrofolate reductase (MTHFR), C677T, results in a thermolabile variant with reduced activity… (More)
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Highly Cited
1998
Highly Cited
1998
A common mutation (C677T) in the gene encoding for methylenetetrahydrofolate reductase (MTHFR) (5-methyltetrahydrofolate… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND Methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate, the major carbon donor in… (More)
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Highly Cited
1995
Highly Cited
1995
Hyperhomocysteinaemia has been identified as a risk factor for cerebrovascular, peripheral vascular and coronary heart disease1–4… (More)
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Highly Cited
1994
Highly Cited
1994
Methylenetetrahydrofolate reductase (MTHFR) catalyses the reduction of methylenetetrahydrofolate to methyltetrahydrofolate, a… (More)
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