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MSH6 protein, human

Known as: 160-kDa GTBP, human, MutS-alpha 160 kDa subunit, human, G/T Mismatch Binding Protein 
DNA mismatch repair protein Msh6 (1360 aa, ~153 kDa) is encoded by the human MSH6 gene. This protein is involved in the DNA damage response.
National Institutes of Health

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13 relations
Cell NucleusDNA RepairDNA Repair GeneDNA repair protein

Papers overview

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2017
2017
Prognostic values of detecting MSI phenotypes in colorectal carcinoma by immunohistochemical method compared to molecular investigation.
BACKGROUND The identification essentially of hMSH2 and/or hMLH1 alterations has clinical implications for recognition and… 
2014
2014
Diagnostic application of hMLH 1 methylation in hereditary non-polyposis colorectal cancer 1
Colorectal cancer (CRC) due to mismatch repair (MMR) defect has distinct characteristics among unselected CRCs. These CRCs are… 
2007
2007
Bcl 2 Impedes DNA Mismatch Repair by Directly Regulating the hMSH 2-hMSH 6 Heterodimeric Complex *
Bcl2 has been reported to suppress DNA mismatch repair (MMR)with promotion ofmutagenesis, but themechanism(s) is not fully… 
2002
2002
Expression of the hMSH 6 mismatch-repair protein in colon cancer and HeLa cells
A phenotype characterised by widespread instability of microsatellite sequences in DNA has been reported to occur in 10–15% of… 
2002
2002
Loss of hMSH 2 and hMSH 6 Expression Is Frequent in Sporadic Endometrial Carcinomas with Microsatellite Instability : A Population-based Study 1
Microsatellite instability (MSI) seems to be important in the development of various human cancers including sporadic endometrial… 
2000
2000
Incidence of germline hMLH 1 and hMSH 2 mutations ( HNPCC patients ) among newly diagnosed colorectal cancers in a Slovenian population
  • 2000
  • Corpus ID: 261722090
EDITOR—Hereditary non-polyposis colorectal cancer (HNPCC) syndrome is a common autosomal dominant predisposition to colorectal… 
1999
1999
hMSH2 and GTBP expression in advanced stage epithelial ovarian cancer
SummaryDefects in DNA mismatch repair have been associated with both hereditary and sporadic forms of human cancer. Most of the… 
1999
1999
3 Functional analysis of human MutS a and MutS b complexes in
1998 ABSTRACT Mismatch repair (MMR) is initiated when a heterodimer of hMSH2 • hMSH6 or hMSH2 • hMSH3 binds to mismatches. Here… 
1998
1998
RER phenotype and its associated mutations in familial gastric cancer.
To clarify the genetic background of gastric cancer, we collected 28 familial gastric cancers (FGCs) with reference to the… 
1998
1998
Molekulare Krebsdispositionsdiagnostik am Beispiel des kolorektalen Karzinoms**Welchen Beitrag kann die Pathologie leisten?
ZusammenfassungDie Aufklärung der molekularen Grundlagen einer Reihe erblicher Krebsdispositionssyndrome eröffnet bislang nicht… 
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