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MSH6 protein, human

Known as: 160-kDa GTBP, human, MutS-alpha 160 kDa subunit, human, G/T Mismatch Binding Protein 
DNA mismatch repair protein Msh6 (1360 aa, ~153 kDa) is encoded by the human MSH6 gene. This protein is involved in the DNA damage response.
National Institutes of Health

Related topics

Related topics

13 relations
Cell NucleusDNA RepairDNA Repair GeneDNA repair protein

Papers overview

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Highly Cited
2002
Highly Cited
2002
Involvement of hMSH6 in the development of hereditary and sporadic colorectal cancer revealed by immunostaining is based on germline mutations, but rarely on somatic inactivation
Germline mutations in human mismatch repair (MMR) genes yield a predisposition for the hereditary nonpolyposis colon cancer… 
Highly Cited
2002
Highly Cited
2002
Human colon cancer cells surviving high doses of cisplatin or oxaliplatin in vitro are not defective in DNA mismatch repair proteins
Purpose. Alterations in the DNA mismatch repair (MMR) proteins have been associated with an increased resistance of many cancer… 
Highly Cited
2001
Highly Cited
2001
Asymmetric Recognition of DNA Local Distortion
Crystal structures of bacterial MutS homodimers bound to mismatched DNA reveal asymmetric interactions of the two subunits with… 
Highly Cited
2001
Highly Cited
2001
PTEN gene mutations in colorectal cancers displaying microsatellite instability.
Highly Cited
2001
Highly Cited
2001
Alterations of Mismatch Repair Protein Expression in Benign Melanocytic Nevi, Melanocytic Dysplastic Nevi, and Cutaneous Malignant Melanomas
Immunoperoxidase-staining methods were used to examine the expression of hMLH1, hMSH2, and hMSH6 mismatch repair (MMR) proteins… 
Highly Cited
2001
Highly Cited
2001
Lack of MSH2 and MSH6 characterizes endometrial but not colon carcinomas in hereditary nonpolyposis colorectal cancer.
Hereditary nonpolyposis colorectal cancer syndrome is associated with an inherited predisposition to primarily colorectal cancer… 
Highly Cited
2001
Highly Cited
2001
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1
We have identified the physical interaction between the Breast Cancer susceptibility gene product BRCA1 and the Hereditary Non… 
Highly Cited
1999
Highly Cited
1999
Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6‐methylguanine‐DNA methyltransferase and N‐methylpurine‐DNA glycosylase in melanoma cells with acquired drug resistance
Malignant melanoma is well known for its primary unresponsiveness to chemotherapy. The mechanisms conferring this intrinsic… 
Highly Cited
1996
Highly Cited
1996
Human MutSα Specifically Binds to DNA Containing Aminofluorene and Acetylaminofluorene Adducts*
Defects in mismatch repair are associated with several types of cancer. It is also generally believed that environmental… 
Highly Cited
1988
Highly Cited
1988
Characterization of an islet-activating protein-sensitive site in mouse sperm that is involved in the zona pellucida-induced acrosome reaction.
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