MSH6 protein, human

Known as: 160-kDa GTBP, human, MutS-alpha 160 kDa subunit, human, G/T Mismatch Binding Protein 
DNA mismatch repair protein Msh6 (1360 aa, ~153 kDa) is encoded by the human MSH6 gene. This protein is involved in the DNA damage response.
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
PURPOSE Over the past few years, the alkylating agent temozolomide has become the standard-of-care therapy for patients with… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND & AIMS Hereditary nonpolyposis colorectal carcinoma (HNPCC) is caused by a mutated mismatch repair (MMR) gene. The aim… (More)
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Highly Cited
2001
Highly Cited
2001
Hereditary non-polyposis colorectal cancer (HNPCC) is the most common genetic susceptibility syndrome for colorectal cancer… (More)
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Highly Cited
2000
Highly Cited
2000
Eukaryotic DNA mismatch repair requires the concerted action of several proteins, including proliferating cell nuclear antigen… (More)
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Highly Cited
1999
Highly Cited
1999
Hereditary nonpolyposis colorectal cancer (HNPCC) (Amsterdam criteria) is often caused by mutations in mismatch repair (MMR… (More)
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Highly Cited
1999
Highly Cited
1999
Cancer predisposition in hereditary non-polyposis colon cancer (HNPCC) is caused by defects in DNA mismatch repair (MMR… (More)
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Highly Cited
1999
Highly Cited
1999
Oxidation of G in DNA yields 8-oxo-G (GO), a mutagenic lesion that leads to misincorporation of A opposite GO. In E. coli, GO in… (More)
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Highly Cited
1998
Highly Cited
1998
Three human genes, hMSH2, hMSH3, and hMSH6, are homologues of the bacterial MutS gene whose products bind DNA mismatches to… (More)
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Highly Cited
1996
Highly Cited
1996
Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to the bacterial MutS protein. In this study… (More)
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Highly Cited
1995
Highly Cited
1995
DNA mismatch recognition and binding in human cells has been thought to be mediated by the hMSH2 protein. Here it is shown that… (More)
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