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MMP14 wt Allele

Known as: MTMMP1, MMP-X1, MT1-MMP 
Human MMP14 wild-type allele is located within 14q11-q12 and is approximately 11 kb in length. This allele, which encodes matrix metalloproteinase-14… 
National Institutes of Health

Related topics

Related topics

7 relations
14q11-q12HydrolysisInhibition of Matrix Metalloproteinases PathwayMMP14 protein, human

Broader (1)

MMP14 gene

Papers overview

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Highly Cited
2016
Highly Cited
2016
p63/MT1-MMP axis is required for in situ to invasive transition in basal-like breast cancer
The transition of ductal carcinoma in situ (DCIS) to invasive breast carcinoma requires tumor cells to cross the basement… 
Highly Cited
2013
Highly Cited
2013
Shedding of Discoidin Domain Receptor 1 by Membrane-type Matrix Metalloproteinases*
Background: DDR1 is a receptor tyrosine kinase that signals in response to collagen and regulates cell-collagen interactions. MT… 
2013
2013
MT1-MMP in breast cancer: induction of VEGF-C correlates with metastasis and poor prognosis
BackgroundRecent evidence suggests that vascular endothelial growth factor-C (VEGF-C)- dependent tumour production promotes… 
2010
2010
YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis.
2010
2010
Increased serum level of membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) in patients with breast cancer.
UNLABELLED Different types of matrix metalloproteinases, including membrane type 1 matrix metalloproteinase (MT1-MMP/MMP-14) can… 
Highly Cited
2005
Highly Cited
2005
Upregulated MT1-MMP/TIMP-2 axis in the TSU-Pr1-B1/B2 model of metastatic progression in transitional cell carcinoma of the bladder
Muscle invasive transitional cell carcinoma (TCC) of the bladder is associated with a high frequency of metastasis, resulting in… 
Highly Cited
2004
Highly Cited
2004
Enhanced production and activation of progelatinase A mediated by membrane-type 1 matrix metalloproteinase in human oral squamous cell carcinomas: Implications for lymph node metastasis
We measured the production levels of seven different matrix metalloproteinases (MMP-1, 2, 3, 7, 8, 9 and 13) and two tissue… 
Highly Cited
2003
Highly Cited
2003
Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumors
Membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP-14) has been believed a key enzyme in tumor invasion, because it is… 
Highly Cited
2002
Highly Cited
2002
On the role of MT1-MMP, a matrix metalloproteinase essential to collagen remodeling, in murine molar eruption and root growth.
Although the connective tissues of the periodontium are subject to a high turnover rate, no conclusive evidence has yet emerged… 
Highly Cited
1997
Highly Cited
1997
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.
Activation of the zymogen of matrix metalloproteinase 2 (proMMP-2, progelatinase A) possibly is one of the key steps in invasion… 
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