Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumors

@article{Ueda2003SequencespecificSO,
  title={Sequence-specific silencing of MT1-MMP expression suppresses tumor cell migration and invasion: importance of MT1-MMP as a therapeutic target for invasive tumors},
  author={Junko Ueda and Masahiro Kajita and Naoko Suenaga and Katsuyuki Fujii and Motoharu Seiki},
  journal={Oncogene},
  year={2003},
  volume={22},
  pages={8716-8722}
}
Membrane-type 1 matrix metalloproteinase (MT1-MMP/MMP-14) has been believed a key enzyme in tumor invasion, because it is expressed in a variety of malignant human tumors, and overexpression of the enzyme enhances the ability of cellular invasiveness. However, it has not necessarily been clarified whether the endogenously expressed MT1-MMP in human tumors plays a critical role in their invasiveness. We used RNA silencing technology to downregulate the endogenous MT1-MMP expression in human… CONTINUE READING
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Showing 1-10 of 10 references

Am

  • I Okamoto, H Tsuiki, +11 authors AJ. Wong
  • J. Pathol., 160, 441–447.
  • 2002
1 Excerpt

Biol

  • CM Overall, GA McQuibban, I. Clark-Lewis
  • Chem., 383, 1059–1066.
  • 2002
3 Excerpts

Curr

  • M. Seiki
  • Opin. Cell Biol., 14, 624–632.
  • 2002

J

  • BI Ratnikov, DV Rozanov, +7 authors AY. Strongin
  • Biol. Chem., 277, 7377–7385.
  • 2002

Nat

  • DJ Webb, JT Parsons, AF. Horwitz
  • Cell Biol., 4, E97–E100.
  • 2002

Semin

  • WG Stetler-Stevenson, Yu AE.
  • Cancer Biol., 11, 143–152.
  • 2001

Mol

  • I Yana, Weiss SJ.
  • Biol. Cell, 11, 2387–2401.
  • 2000

Proc

  • Z Zhou, SS Apte, +6 authors K. Tryggvason
  • Natl. Acad. Sci. USA, 97, 4052–4057.
  • 2000
2 Excerpts

Verh

  • Y. Okada
  • Dtsch. Ges. Pathol., 84, 33–42.
  • 2000
2 Excerpts

Adv

  • D Naot, RV Sionov, D. Ish-Shalom
  • Cancer Res., 71, 241–319.
  • 1997
3 Excerpts

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