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MKC 442

Known as: MKC-442 
National Institutes of Health

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emivirine

Papers overview

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2005
2005
Synthesis and evaluation of double-prodrugs against HIV. Conjugation of D4T with 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine)-type reverse transcriptase inhibitors via the SATE…
This paper reports the synthesis and the antiviral activities of new double-prodrugs against HIV based on the known mixed SATE (S… 
2004
2004
Synthesis of Furoannelated Analogues of Emivirine (MKC‐442)
Furoannelated analogues 1‐alkoxymethyl‐7‐phenyl‐5, 7‐dihydro‐1H‐furo[3, 4‐d]‐pyrimidine‐2, 4‐diones of Emivirine (3a, b) were… 
2003
2003
Synthesis of Novel MKC‐442 Analogues with Potent Activities against HIV‐1
Bis(alken‐1‐yloxy)methanes 2 were synthesized by reacting 2‐cyclohexenol, 3‐cyclohexenylmethanol, cinnamyl alcohol and its… 
2003
2003
Synthesis and evaluation of new potential HIV-1 non-nucleoside reverse transcriptase inhibitors. New analogues of MKC-442 containing Michael acceptors in the C-6 position.
Analogues of MKC-442 capable of undergoing Michael addition reactions were synthesised in order to investigate the activity… 
2001
2001
Synthesis of nucleoside analogs and new Tat protein inhibitors
Two studies, concerning the synthesis of original nucleoside analogs regarded as an application of heterochemistry on… 
2000
2000
Safety Assessment, In Vitro and In Vivo, and Pharmacokinetics of Emivirine, a Potent and Selective Nonnucleoside Reverse Transcriptase Inhibitor of Human Immunodeficiency Virus Type 1
ABSTRACT Emivirine (EMV), formerly known as MKC-442, is 6-benzyl-1-(ethoxymethyl)-5-isopropyl-uracil, a novel nonnucleoside… 
1999
1999
N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency…
1999
1999
N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.
1997
1997
Three‐drug combination of MKC‐442, lamivudine and zidovudine in vitro: potential approach towards effective chemotherapy against HIV‐1
Objectives:MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil), a potent non-nucleoside reverse transcriptase inhibitor, is a… 
1995
1995
The inhibition of human immunodeficiency virus type 1 in vitro by a non-nucleoside reverse transcriptase inhibitor MKC-442, alone and in combination with other anti-HIV compounds.
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