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MKC 442

Known as: MKC-442 
 
National Institutes of Health

Papers overview

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2003
2003
Bis(alken‐1‐yloxy)methanes 2 were synthesized by reacting 2‐cyclohexenol, 3‐cyclohexenylmethanol, cinnamyl alcohol and its… Expand
Highly Cited
2002
Highly Cited
2002
This paper reports the synthesis and the antiviral activities of a series of 6-arylmethyl-1-(allyloxymethyl)-5-alkyluracil… Expand
Review
2001
Review
2001
  • E. De Clercq
  • Current medicinal chemistry
  • 2001
  • Corpus ID: 23439270
Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV infections… Expand
Highly Cited
1999
Highly Cited
1999
Two analogues of the nonnucleoside inhibitor of HIV-1 RT, MKC-442 (emivirine), containing different C6 substituents have been… Expand
Highly Cited
1999
Highly Cited
1999
BACKGROUND After the initial discovery of 1-(2-hydroxyethoxymethyl)-6-(phenylthio)thymine (HEPT) and tetrahydroimidazo[4,5,1-jk… Expand
Review
1998
Review
1998
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) have, in addition to the nucleoside reverse transcriptase inhibitors… Expand
Highly Cited
1996
Highly Cited
1996
Crystal structures of HIV-1 reverse transcriptase (RT) complexed with a range of chemically diverse non-nucleoside inhibitors… Expand
1995
1995
MKC-442, a derivative of the non-nucleoside reverse transcriptase (RT) inhibitor 1-[(2-hydroxyethoxy)methyl)-6-(phenylthio… Expand
Highly Cited
1994
Highly Cited
1994
MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil or I-EBU) has recently been identified as a highly potent and specific… Expand
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1993
1993
In the search for 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives, we have found 6-benzyl-1-(ethoxymethyl)-5… Expand