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MKC 442

Known as: MKC-442 
National Institutes of Health

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Broader (1)

emivirine

Papers overview

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Highly Cited
2011
Highly Cited
2011
Epigallocatechin Gallate Inhibits the HIV Reverse Transcription Step
Background: Epigallocatechin gallate (EGCG), the most abundant catechin in green tea, has been reported to inhibit HIV-1… 
2007
2007
The design and synthesis of N-1-alkylated-5-aminoarylalkylsubstituted-6-methyluracils as potential non-nucleoside HIV-1 RT inhibitors.
2003
2003
Synthesis of Novel MKC‐442 Analogues with Potent Activities against HIV‐1
Bis(alken‐1‐yloxy)methanes 2 were synthesized by reacting 2‐cyclohexenol, 3‐cyclohexenylmethanol, cinnamyl alcohol and its… 
Highly Cited
2002
Highly Cited
2002
Synthesis of novel N-1 (allyloxymethyl) analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine) with improved activity against HIV-1 and its mutants.
This paper reports the synthesis and the antiviral activities of a series of 6-arylmethyl-1-(allyloxymethyl)-5-alkyluracil… 
Review
1999
Review
1999
Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection.
Highly Cited
1999
Highly Cited
1999
Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.
1999
1999
N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.
1999
1999
N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency…
1997
1997
Three‐drug combination of MKC‐442, lamivudine and zidovudine in vitro: potential approach towards effective chemotherapy against HIV‐1
Objectives:MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil), a potent non-nucleoside reverse transcriptase inhibitor, is a… 
1993
1993
Selective and synergistic inhibition of human immunodeficiency virus type 1 reverse transcriptase by a non-nucleoside inhibitor, MKC-442.
In the search for 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives, we have found 6-benzyl-1-(ethoxymethyl)-5… 
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