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MKC 442
Known as:
MKC-442
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
emivirine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
The design and synthesis of N-1-alkylated-5-aminoarylalkylsubstituted-6-methyluracils as potential non-nucleoside HIV-1 RT inhibitors.
X. Lu
,
Yanli Chen
,
+6 authors
Junyi Liu
Bioorganic & medicinal chemistry
2007
Corpus ID: 38643875
Highly Cited
2002
Highly Cited
2002
Synthesis of novel N-1 (allyloxymethyl) analogues of 6-benzyl-1-(ethoxymethyl)-5-isopropyluracil (MKC-442, emivirine) with improved activity against HIV-1 and its mutants.
N. R. El‐Brollosy
,
P. T. Jørgensen
,
Berit Dahan
,
A. Boel
,
E. Pedersen
,
C. Nielsen
Journal of medicinal chemistry
2002
Corpus ID: 40596590
This paper reports the synthesis and the antiviral activities of a series of 6-arylmethyl-1-(allyloxymethyl)-5-alkyluracil…
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Review
2001
Review
2001
New developments in anti-HIV chemotherapy
E. De Clercq
Current medicinal chemistry
2001
Corpus ID: 23439270
Abstract Virtually all the compounds that are currently used, or under advanced clinical trial, for the treatment of HIV…
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Highly Cited
1999
Highly Cited
1999
Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
A. Hopkins
,
J. Ren
,
+4 authors
D. Stammers
Journal of medicinal chemistry
1999
Corpus ID: 21942637
Two analogues of the nonnucleoside inhibitor of HIV-1 RT, MKC-442 (emivirine), containing different C6 substituents have been…
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1999
1999
Rational design of N-[2-(2,5-dimethoxyphenylethyl)]-N'-[2-(5-bromopyridyl)]-thiourea (HI-236) as a potent non-nucleoside inhibitor of drug-resistant human immunodeficiency virus.
C. Mao
,
E. Sudbeck
,
T. Venkatachalam
,
F. Uckun
Bioorganic & medicinal chemistry letters
1999
Corpus ID: 25183904
Review
1999
Review
1999
Perspectives of non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the therapy of HIV-1 infection.
E. De Clercq
Farmaco
1999
Corpus ID: 24132317
1999
1999
N-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-bromopyridyl)]-thiourea and N'-[2-(1-cyclohexenyl)ethyl]-N'-[2-(5-chloropyridyl)]-thiourea as potent inhibitors of multidrug-resistant human immunodeficiency…
F. Uckun
,
C. Mao
,
+4 authors
T. Venkatachalam
Bioorganic & medicinal chemistry letters
1999
Corpus ID: 9319754
1999
1999
N'-[2-(2-thiophene)ethyl]-N'-[2-(5-bromopyridyl)] thiourea as a potent inhibitor of NNI-resistant and multidrug-resistant human immunodeficiency virus-1.
F. Uckun
,
S. Pendergrass
,
+4 authors
T. Venkatachalam
Bioorganic & medicinal chemistry letters
1999
Corpus ID: 20711884
Highly Cited
1996
Highly Cited
1996
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.
A. Hopkins
,
Jingshan Ren
,
+8 authors
D. Stuart
Journal of medicinal chemistry
1996
Corpus ID: 27924228
Crystal structures of HIV-1 reverse transcriptase (RT) complexed with a range of chemically diverse non-nucleoside inhibitors…
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Highly Cited
1994
Highly Cited
1994
Preclinical evaluation of MKC-442, a highly potent and specific inhibitor of human immunodeficiency virus type 1 in vitro
M. Baba
,
S. Shigeta
,
+7 authors
E. De Clercq
Antimicrobial Agents and Chemotherapy
1994
Corpus ID: 30758261
MKC-442 (6-benzyl-1-ethoxymethyl-5-isopropyluracil or I-EBU) has recently been identified as a highly potent and specific…
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