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MKC 242

Known as: MKC-242 
National Institutes of Health

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osemozotan

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Highly Cited
2003
Highly Cited
2003
Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex
Highly Cited
2003
Highly Cited
2003
The 5-HT1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice
RationalePrepulse inhibition (PPI) of startle provides an operational measure of sensorimotor gating in which a weak stimulus… 
2002
2002
Extended action of MKC‐242, a selective 5‐HT1A receptor agonist, on light‐induced Per gene expression in the suprachiasmatic nucleus in mice
We reported previously that (S)‐5‐[3‐[(1,4‐benzodioxan‐2‐ylmethyl)amino]propoxy]‐1,3‐benzodioxole hydrochloride (MKC‐242) (3 mg… 
Highly Cited
2001
Highly Cited
2001
Palladium-catalyzed intramolecular C-O bond formation.
A number of oxygen heterocycles were synthesized using the palladium-catalyzed intramolecular etherification of aryl halides by… 
Highly Cited
1998
Highly Cited
1998
Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist.
The aminomethylchroman derivative BAY x 3702 (R-(-)-2-[4-[(chroman-2-ylmethyl)-amino]-butyl]-1,1-dioxo-benzo[d] isothiazolone… 
1998
1998
Potentiating action of MKC‐242, a selective 5‐HT1A receptor agonist, on the photic entrainment of the circadian activity rhythm in hamsters
1 Serotonergic projections from the midbrain raphe nuclei to the suprachiasmatic nuclei (SCN) are known to regulate the photic… 
Highly Cited
1996
Highly Cited
1996
Mixing renormalization in Majorana neutrino theories
1996
1996
Novel benzodioxan derivative, 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl) amino]propoxy]-1,3-benzodioxole HCl (MKC-242), with anxiolytic-like and antidepressant-like effects in animal models.
Behavioral effects of MKC-242 (5-{3-[((2>)-1,4-benzodioxan-2-ylmethyl)amino] propoxy}-1,3-benzodioxole CHl), a novel and… 
Highly Cited
1995
Highly Cited
1995
Novel benzodioxan derivative, 5-(3-[((2S)-1,4-benzodioxan-2- ylmethyl)amino]propoxy)-1,3-benzodioxole HCl (MKC-242), with a highly potent and selective agonist activity at rat central serotonin1A…
The present study characterizes the neurochemical profile of the newly synthesized compound 5-(3-[((2S)-1,4-benzodioxan-2… 
Highly Cited
1995
Highly Cited
1995
Antidepressant-like effect by postsynaptic 5-HT1A receptor activation in mice.
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