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MKC 242

Known as: MKC-242 
National Institutes of Health

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osemozotan

Papers overview

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2013
2013
Two distinct serotonin receptors co-mediate non-photic signals to the circadian clock.
Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the… 
2005
2005
Inhibitory action of 5-HT1A agonist MKC-242 on triazolam-induced phase advances in hamster circadian activity rhythms.
Mammalian circadian rhythms can be entrained by photic and non-photic stimuli. Although we know that non-photic entrainment… 
Highly Cited
2003
Highly Cited
2003
Regulation by 5-HT1A receptors of the in vivo release of 5-HT and DA in mouse frontal cortex
2002
2002
Extended action of MKC‐242, a selective 5‐HT1A receptor agonist, on light‐induced Per gene expression in the suprachiasmatic nucleus in mice
We reported previously that (S)‐5‐[3‐[(1,4‐benzodioxan‐2‐ylmethyl)amino]propoxy]‐1,3‐benzodioxole hydrochloride (MKC‐242) (3 mg… 
2002
2002
Selective reduction by isolation rearing of 5‐HT1A receptor‐mediated dopamine release in vivo in the frontal cortex of mice
Serotonin (5‐HT)1A receptors modulate in vivo release of brain monoaminergic neurotransmitters which may be involved in isolation… 
2001
2001
Involvement of benzodiazepine binding sites in an antiaggressive effect by 5-HT(1A) receptor activation in isolated mice.
2001
2001
[Behavioral and neurochemical study on the mechanism of the anxiolytic effect of a selective serotonin reuptake inhibitor, a selective serotonin1A agonist and lithium carbonate].
The authors investigated the effects of citalopram [selective serotonin (5-HT) reuptake inhibitor; SSRI] and MKC-242 (a selective… 
1998
1998
Reduction of wrap restraint stress-induced defecation by MKC-242, a novel benzodioxan derivative, via 5-HT1A-receptor agonist action in rats.
Effects of MKC-242 (5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-b enzodioxole HC1), a novel 5-HT1A-receptor agonist… 
1997
1997
Interaction of orally administered 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy]-1,3-benzodioxole (MKC-242) with 5-HT1A receptors in rat brain.
The present study was carried out to clarify whether orally administered 5-{3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy}-1… 
1997
1997
MKC-242, a novel 5-HT1A receptor agonist, facilitates cortical acetylcholine release by a mechanism different from that of 8-OH-DPAT in awake rats
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