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MKC 242

Known as: MKC-242 
 
National Institutes of Health

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osemozotan

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Highly Cited
2003
Highly Cited
2003
The 5-HT1A receptor agonist MKC-242 reverses isolation rearing-induced deficits of prepulse inhibition in mice
RationalePrepulse inhibition (PPI) of startle provides an operational measure of sensorimotor gating in which a weak stimulus… Expand
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2002
2002
Extended action of MKC‐242, a selective 5‐HT1A receptor agonist, on light‐induced Per gene expression in the suprachiasmatic nucleus in mice
We reported previously that (S)‐5‐[3‐[(1,4‐benzodioxan‐2‐ylmethyl)amino]propoxy]‐1,3‐benzodioxole hydrochloride (MKC‐242) (3 mg… Expand
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Highly Cited
2001
Highly Cited
2001
Palladium-catalyzed intramolecular C-O bond formation.
A number of oxygen heterocycles were synthesized using the palladium-catalyzed intramolecular etherification of aryl halides by… Expand
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1999
1999
Effect of subchronic lithium carbonate treatment on anxiolytic-like effect of citalopram and MKC-242 in conditioned fear stress in the rat.
We investigated the effect of citalopram [selective serotonin (5-HT) reuptake inhibitor] and MKC-242 (5-[3-¿(2S)-(1, 4… Expand
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Highly Cited
1998
Highly Cited
1998
Characterization of the aminomethylchroman derivative BAY x 3702 as a highly potent 5-hydroxytryptamine1A receptor agonist.
The aminomethylchroman derivative BAY x 3702 (R-(-)-2-[4-[(chroman-2-ylmethyl)-amino]-butyl]-1,1-dioxo-benzo[d] isothiazolone… Expand
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1998
1998
Potentiating action of MKC‐242, a selective 5‐HT1A receptor agonist, on the photic entrainment of the circadian activity rhythm in hamsters
1 Serotonergic projections from the midbrain raphe nuclei to the suprachiasmatic nuclei (SCN) are known to regulate the photic… Expand
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1997
1997
MKC-242, a novel 5-HT1A receptor agonist, facilitates cortical acetylcholine release by a mechanism different from that of 8-OH-DPAT in awake rats
We have previously reported that 5-¿3-[((2S)-1,4-benzodioxan-2-ylmethyl)amino]propoxy¿-1,3-be nzodioxole (MKC-242), a potent and… Expand
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Highly Cited
1996
Highly Cited
1996
Mixing renormalization in Majorana neutrino theories
The renormalization of general theories with inter-family mixing of Dirac and/or Majorana fermions is studied at the one-loop… Expand
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1996
1996
Novel benzodioxan derivative, 5-[3-[((2S)-1,4-benzodioxan-2-ylmethyl) amino]propoxy]-1,3-benzodioxole HCl (MKC-242), with anxiolytic-like and antidepressant-like effects in animal models.
Behavioral effects of MKC-242 (5-{3-[((2>)-1,4-benzodioxan-2-ylmethyl)amino] propoxy}-1,3-benzodioxole CHl), a novel and… Expand
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Highly Cited
1995
Highly Cited
1995
Novel benzodioxan derivative, 5-(3-[((2S)-1,4-benzodioxan-2- ylmethyl)amino]propoxy)-1,3-benzodioxole HCl (MKC-242), with a highly potent and selective agonist activity at rat central serotonin1A…
The present study characterizes the neurochemical profile of the newly synthesized compound 5-(3-[((2S)-1,4-benzodioxan-2… Expand
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