Two distinct serotonin receptors co-mediate non-photic signals to the circadian clock.

@article{Horikawa2013TwoDS,
  title={Two distinct serotonin receptors co-mediate non-photic signals to the circadian clock.},
  author={Kazumasa Horikawa and Kazuyuki Fuji and Yuka Fukazawa and Shigenobu Shibata},
  journal={Journal of pharmacological sciences},
  year={2013},
  volume={123 4},
  pages={402-6}
}
Several lines of evidence indicate that serotonin type 7 (5-HT7) receptors play a critical role for non-photic resetting of the mammalian circadian clock; however, the contributions of other types of 5-HT receptors to non-photic entrainment are not yet clarified. The present study demonstrates that MKC-242, a selective 5-HT1A receptor agonist, can evoke a non-photic-like phase-response in hamsters in vivo. This phase-shifting response to MKC-242 was antagonized not only by the selective 5-HT1A… CONTINUE READING

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