Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 237,162,764 papers from all fields of science
Search
Sign In
Create Free Account
MK-8776
Known as:
CHK1 Inhibitor MK-8776
, Sch900776
, Sch-900776
Expand
An agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. Chk1 inhibitor MK-8776…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
3 relations
NCIt Antineoplastic Agent Terminology
Broader (2)
Pyrazoles
Pyrimidines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Chk1 inhibition via MK-8776 confers antitumor efficacy alone and enhances cytotoxicity of gemcitabine in high grade serous epithelial ovarian cancer tumorgrafts
Amanika Kumar
2016
Corpus ID: 78600738
2013
2013
Cancer Therapy : Preclinical Sensitization of Pancreatic Cancer to Chemoradiation by the Chk 1 Inhibitor MK 8776
Carl G. Engelke
,
L. Parsels
,
+12 authors
M. Morgan
2013
Corpus ID: 31051062
Purpose: The combination of radiationwith chemotherapy is themost effective therapy for unresectable pancreatic cancer. To…
Expand
2013
2013
Abstract 3413: Dissecting the combination of gemcitabine and the Chk1 inhibitor MK-8776in vitroandin vivo: cell cycle perturbation and the impact of administration schedule.
A. Eastman
,
R. Montano
,
+5 authors
M. Ernstoff
2013
Corpus ID: 72686128
Gemcitabine inhibits ribonucleotide reductase, prevents synthesis of deoxyribonucleotides, and induces arrest of cells in S phase…
Expand
2012
2012
Cancer Therapy : Preclinical Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells In Vitro
Erin L. Schenk
,
Brian D. Koh
,
+7 authors
S. Kaufmann
2012
Corpus ID: 9338854
Purpose: Previous studies have shown that the replication checkpoint, which involves the kinases ataxia telangiectasiamutated…
Expand