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MK 0646

Known as: MK-0646, MK0646 
National Institutes of Health

Papers overview

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2018
2018
BackgroundBinding of insulin-like growth factor-I (IGF-1) to its receptor (IGF-1R) initiates downstream signals that activate… 
Highly Cited
2015
Highly Cited
2015
Significance Most preclinical drug screening systems fail to predict whether a given drug candidate will succeed in clinical… 
2014
2014
Despite numerous therapies that effectively inhibit estrogen signaling in breast cancer, a significant proportion of patients… 
2014
2014
The development and characterization of effective anticancer drugs against colorectal cancer (CRC) is of urgent need since it is… 
Highly Cited
2012
Highly Cited
2012
Neuroendocrine tumor (NET) cell lines frequently express both insulin‐like growth factor (IGF) ligand and the cognate IGF‐1… 
Highly Cited
2011
Highly Cited
2011
Purpose: Insulin-like growth factor-1 receptor (IGF-1R) mediates cellular processes in cancer and has been proposed as a… 
2010
2010
4039 Background: MK-0646 binds to IGF-1R and blocks its interaction with IGF-I/ II ligands, enhances gemcitabine (G)-induced… 
2008
2008
3520 Background: IGF1R is a receptor tyrosine kinase which is overexpressed in many primary tumor cells, including breast, colon…