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MK 0646

Known as: MK-0646, MK0646 
 
National Institutes of Health

Papers overview

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2014
2014
Despite numerous therapies that effectively inhibit estrogen signaling in breast cancer, a significant proportion of patients… Expand
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2014
2014
The development and characterization of effective anticancer drugs against colorectal cancer (CRC) is of urgent need since it is… Expand
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2014
2014
The insulin-like growth factor receptor is a potential target in small-cell lung cancer. We conducted a phase I study of… Expand
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Highly Cited
2012
Highly Cited
2012
Neuroendocrine tumor (NET) cell lines frequently express both insulin‐like growth factor (IGF) ligand and the cognate IGF‐1… Expand
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Highly Cited
2011
Highly Cited
2011
Purpose: Insulin-like growth factor-1 receptor (IGF-1R) mediates cellular processes in cancer and has been proposed as a… Expand
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2011
2011
Purpose: Malignant peripheral nerve sheath tumor (MPNST) is a rare sarcoma that lacks effective therapeutic strategies. We gain… Expand
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2010
2010
4039 Background: MK-0646 binds to IGF-1R and blocks its interaction with IGF-I/ II ligands, enhances gemcitabine (G)-induced… Expand
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2010
2010
4163 Background: Preclinical studies have implicated the IGF-1 receptor in the progression of neuroendocrine tumors. A therapy… Expand
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2009
2009
4127 Background: Evidence of cross-talk between EGFR and IGFR signaling pathways provide a logical rationale for combining anti… Expand
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2008
2008
3520 Background: IGF1R is a receptor tyrosine kinase which is overexpressed in many primary tumor cells, including breast, colon… Expand
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