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MK 0646

Known as: MK-0646, MK0646 
National Institutes of Health

Papers overview

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2018
2018
BackgroundBinding of insulin-like growth factor-I (IGF-1) to its receptor (IGF-1R) initiates downstream signals that activate… Expand
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Highly Cited
2015
Highly Cited
2015
Significance Most preclinical drug screening systems fail to predict whether a given drug candidate will succeed in clinical… Expand
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2014
2014
Despite numerous therapies that effectively inhibit estrogen signaling in breast cancer, a significant proportion of patients… Expand
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2014
2014
The development and characterization of effective anticancer drugs against colorectal cancer (CRC) is of urgent need since it is… Expand
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Highly Cited
2012
Highly Cited
2012
Neuroendocrine tumor (NET) cell lines frequently express both insulin‐like growth factor (IGF) ligand and the cognate IGF‐1… Expand
Review
2012
Review
2012
  • E. R. King, K. Wong
  • Recent patents on anti-cancer drug discovery
  • 2012
  • Corpus ID: 23669400
The insulin-like growth factor (IGF) family and the IGF-1 receptor (IGF-1R) play an important role in cancer. This intricate and… Expand
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Highly Cited
2011
Highly Cited
2011
Purpose: Insulin-like growth factor-1 receptor (IGF-1R) mediates cellular processes in cancer and has been proposed as a… Expand
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2011
2011
3501 Background: Evidence of cross-talk between EGFR and IGFR signaling pathways provide a logical rationale for combining anti… Expand
2010
2010
4039 Background: MK-0646 binds to IGF-1R and blocks its interaction with IGF-I/ II ligands, enhances gemcitabine (G)-induced… Expand
2008
2008
3520 Background: IGF1R is a receptor tyrosine kinase which is overexpressed in many primary tumor cells, including breast, colon… Expand