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The histamine 3 (H3) receptor is a presynaptic autoreceptor in the central nervous system that regulates the synthesis and… Expand BACKGROUND
Current antipsychotic treatments have little impact on the cognitive deficits associated with schizophrenia. It has… Expand OBJECTIVES
We aimed to evaluate the efficacy of the selective H3 receptor inverse agonist MK-0249 to treat excessive daytime… Expand BACKGROUND
It has been suggested that the histamine subtype 3 receptor inverse agonists such as MK-0249 might be effective in… Expand We performed a clinical trial to evaluate the effects of the histamine subtype-3 receptor inverse agonist MK- 0249 on cognition… Expand Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the… Expand H3 antagonists increase the release of brain histamine, acetylcholine, noradrenaline, and dopamine, neurotransmitters that are… Expand Introduction: The histamine H3 receptor (H3R) plays a pivotal role in a plethora of therapeutic areas. Blocking the H3R with… Expand RationaleHistamine and dopamine contribute to the maintenance of wakefulness.ObjectiveThis study aims to conduct an exploratory… Expand The alertness‐promoting effect of MK‐0249 (10 or 50 mg), a histamine subtype‐3 receptor (HRH3) inverse agonist (IA), was… Expand