MK-0249

 
National Institutes of Health

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2014
2014
UNLABELLED The histamine 3 (H3) receptor is a presynaptic autoreceptor in the central nervous system that regulates the synthesis… (More)
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2013
2013
BACKGROUND Current antipsychotic treatments have little impact on the cognitive deficits associated with schizophrenia. It has… (More)
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2013
2013
OBJECTIVES We aimed to evaluate the efficacy of the selective H3 receptor inverse agonist MK-0249 to treat excessive daytime… (More)
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2012
2012
BACKGROUND It has been suggested that the histamine subtype 3 receptor inverse agonists such as MK-0249 might be effective in… (More)
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2012
2012
We performed a clinical trial to evaluate the effects of the histamine subtype-3 receptor inverse agonist MK- 0249 on cognition… (More)
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Review
2011
Review
2011
H(3) antagonists increase the release of brain histamine, acetylcholine, noradrenaline, and dopamine, neurotransmitters that are… (More)
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Review
2011
Review
2011
INTRODUCTION The histamine H(3) receptor (H(3)R) plays a pivotal role in a plethora of therapeutic areas. Blocking the H(3)R with… (More)
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2010
2010
The alertness-promoting effect of MK-0249 (10 or 50 mg), a histamine subtype-3 receptor (HRH3) inverse agonist (IA), was… (More)
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2010
2010
Histamine and dopamine contribute to the maintenance of wakefulness. This study aims to conduct an exploratory analysis of the… (More)
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2010
2010
H 3 antagonists increase the release of brain histamine, ACh, NE and DA, neurotransmitters that are known to modulate cognitive… (More)
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