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MK-0249

 
National Institutes of Health

Papers overview

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2014
2014
The histamine 3 (H3) receptor is a presynaptic autoreceptor in the central nervous system that regulates the synthesis and… Expand
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2013
2013
BACKGROUND Current antipsychotic treatments have little impact on the cognitive deficits associated with schizophrenia. It has… Expand
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2013
2013
OBJECTIVES We aimed to evaluate the efficacy of the selective H3 receptor inverse agonist MK-0249 to treat excessive daytime… Expand
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2012
2012
BACKGROUND It has been suggested that the histamine subtype 3 receptor inverse agonists such as MK-0249 might be effective in… Expand
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2012
2012
We performed a clinical trial to evaluate the effects of the histamine subtype-3 receptor inverse agonist MK- 0249 on cognition… Expand
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Review
2011
Review
2011
H3 antagonists increase the release of brain histamine, acetylcholine, noradrenaline, and dopamine, neurotransmitters that are… Expand
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Review
2011
Review
2011
Introduction: The histamine H3 receptor (H3R) plays a pivotal role in a plethora of therapeutic areas. Blocking the H3R with… Expand
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2010
2010
H 3 antagonists increase the release of brain histamine, ACh, NE and DA, neurotransmitters that are known to modulate cognitive… Expand
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2010
2010
RationaleHistamine and dopamine contribute to the maintenance of wakefulness.ObjectiveThis study aims to conduct an exploratory… Expand
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2010
2010
The alertness‐promoting effect of MK‐0249 (10 or 50 mg), a histamine subtype‐3 receptor (HRH3) inverse agonist (IA), was… Expand
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