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MK-0249

National Institutes of Health

Papers overview

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2014
2014
The histamine 3 (H3) receptor is a presynaptic autoreceptor in the central nervous system that regulates the synthesis and… 
2012
2012
BACKGROUND It has been suggested that the histamine subtype 3 receptor inverse agonists such as MK-0249 might be effective in… 
2012
2012
We performed a clinical trial to evaluate the effects of the histamine subtype-3 receptor inverse agonist MK- 0249 on cognition… 
2012
2012
Essential tremor (ET) is a common movement disorder. Animal studies show that histaminergic modulation may affect the… 
Review
2011
Review
2011
H3 antagonists increase the release of brain histamine, acetylcholine, noradrenaline, and dopamine, neurotransmitters that are… 
Review
2011
Review
2011
Introduction: The histamine H3 receptor (H3R) plays a pivotal role in a plethora of therapeutic areas. Blocking the H3R with… 
2010
2010
RationaleHistamine and dopamine contribute to the maintenance of wakefulness.ObjectiveThis study aims to conduct an exploratory… 
2010
2010
The alertness‐promoting effect of MK‐0249 (10 or 50 mg), a histamine subtype‐3 receptor (HRH3) inverse agonist (IA), was…