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MINAPRINE HCL

Known as: Minaprine Dihydrochloride, 3-(2-morpholino-ethylamino)-4-methyl-6-phenyl pyridazine, dihydrochloride, Minaprine Hydrochloride 
 
National Institutes of Health

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minaprine

Papers overview

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Highly Cited
2007
Highly Cited
2007
3-(4-Chloro-2-Morpholin-4-yl-Thiazol-5-yl)-8-(1-Ethylpropyl)-2,6-Dimethyl-Imidazo[1,2-b]Pyridazine: A Novel Brain-Penetrant, Orally Available Corticotropin-Releasing Factor Receptor 1 Antagonist with…
We describe a novel corticotropin-releasing factor receptor 1 (CRF1) antagonist with advantageous properties for clinical… Expand
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2005
2005
A comparison of the behavioral effects of minaprine, amphetamine and stress
Different types of clinically effective antidepressants prevent the behavioral effects of experimental stress, and some of these… Expand
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Highly Cited
2002
Highly Cited
2002
Molecular and Pharmacological Characterization of GABAA Receptor α1 Subunit Knockout Mice
GABAA receptors mediate fast inhibitory neurotransmission in the central nervous system (CNS), and approximately half of these… Expand
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1995
1995
Novel arylaminopyridazine-GABA receptor antagonists examined electrophysiologically in Ascaris suum.
The structure-activity relationships of 35 novel derivatives of 2-(carboxypropyl)-3-amino-4-methyl-6-phenyl pyridazine (SR 95103… Expand
1991
1991
Antagonist properties of arylaminopyridazine GABA derivatives at the Ascaris muscle GABA receptor.
1. In a previous study, it was shown that the potency order for two arylamino-pyridazine derivatives, SR95531 and SR95103, was… Expand
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1989
1989
Double-blind, placebo-controlled, fixed dose trial of minaprine in patients with major depression.
Minaprine dihydrochloride is a novel psychotropic drug possessing both antidepressant and psycho-stimulant properties. Prior… Expand
Highly Cited
1988
Highly Cited
1988
Serotonin-2 receptor-mediated regulation of release of acetylcholine by minaprine in cholinergic nerve terminal of hippocampus of rat
5-Hydroxytryptamine (5-HT) inhibited the K+-induced release of [3H]acetylcholine [( 3H]ACh) from slices of the hippocampus of the… Expand
1987
1987
Minaprine and imipramine in the treatment of major depressive disorders. A comparative double-blind study.
Minaprine dihydrochloride is an aminopyridazine derivative which is chemically unrelated to other known psychotropic drugs. In… Expand
1986
1986
Effect of the antidepressant minaprine on both forms of monoamine oxidase in the rat.
The antidepressant minaprine (3-(2-morpholino-ethylamino) 4-methyl 6-phenyl pyridazine, dihydrochloride) and its main metabolites… Expand
1982
1982
Pharmacological evaluation of minaprine dihydrochloride, a new psychotropic drug.
Minaprine (3-[2-morpholino-ethlamino]-4-methyl-6-phenyl-pyridazine dihydrochloride; 30038CM; trade name in France: Cantor) is a… Expand
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