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MGS 0039

Known as: MGS-0039, MGS0039 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Role of calcium, glutamate and NMDA in major depression and therapeutic application
Highly Cited
2016
Highly Cited
2016
Rapid and Sustained Antidepressant Action of the mGlu2/3 Receptor Antagonist MGS0039 in the Social Defeat Stress Model: Comparison with Ketamine
Abstract Background: Similar to the N-methyl-D-aspartate receptor antagonist ketamine, the metabotropic glutamate 2/3 receptor… 
Review
2013
Review
2013
Glutamate modulators as potential therapeutic drugs in schizophrenia and affective disorders
Severe psychiatric disorders such as schizophrenia are related to cognitive and negative symptoms, which often are resistant to… 
Highly Cited
2011
Highly Cited
2011
Involvement of the mammalian target of rapamycin signaling in the antidepressant-like effect of group II metabotropic glutamate receptor antagonists
Review
2008
Review
2008
Mood disorders: regulation by metabotropic glutamate receptors.
Highly Cited
2006
Highly Cited
2006
An mGluR2/3 antagonist, MGS0039, exerts antidepressant and anxiolytic effects in behavioral models in rats
RationaleAbnormalities of glutamatergic neurotransmission have been reportedly observed in psychiatric disorders. Previously, we… 
Highly Cited
2006
Highly Cited
2006
A metabotropic glutamate 2/3 receptor antagonist, MGS0039, increases extracellular dopamine levels in the nucleus accumbens shell
Highly Cited
2005
Highly Cited
2005
AMPA receptor stimulation mediates the antidepressant-like effect of a group II metabotropic glutamate receptor antagonist
Highly Cited
2004
Highly Cited
2004
MGS0039: a potent and selective group II metabotropic glutamate receptor antagonist with antidepressant-like activity
Highly Cited
2004
Highly Cited
2004
Increased cell proliferation in the adult mouse hippocampus following chronic administration of group II metabotropic glutamate receptor antagonist, MGS0039.
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