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MGCD516

Known as: Multitargeted Kinase Inhibitor MGCD516 
An orally bioavailable, receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Upon administration, multitargeted kinase… Expand
National Institutes of Health

Papers overview

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Review
2017
Review
2017
&NA; The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins, which are encoded by NTRK1, NTRK2 and… Expand
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2017
2017
Alzheimer’s disease (AD) is a complex, multifactorial disease in which different neuropathological mechanisms are likely involved… Expand
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2016
2016
Sarcomas are rare but highly aggressive mesenchymal tumors with a median survival of 10–18 months for metastatic disease… Expand
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2016
2016
A new series of 2-amino-4-oxo-6-substituted pyrrolo[2,3-d]pyrimidines, with an isosteric replacement of the side chain amide… Expand
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2013
2013
Modification of drug delivery nanomaterials with affinity molecules that facilitate targeting, has rendered a new class of… Expand
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2013
2013
Dietary phytochemicals as adjuvants have been suggested to play important roles in enhancing chemotherapeutic potential owing to… Expand
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2012
2012
One of the central unanswered questions in prostate cancer research is the significance of tyrosine kinase inhibitor (TKI… Expand
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Review
2006
Review
2006
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal cancer of teh gastrointestinal tract. They are… Expand
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2005
2005
563 Background: Autocrine and paracrine signaling involving VEGFR and PDGFR are implicated in angiogenesis and proliferation of… Expand
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Highly Cited
2000
Highly Cited
2000
The scheduling of antifolate antitumor agents, including the new multitargeted autofolate LY231514 (MTA), with 5-fluorouracil was… Expand
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