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MFSD2A gene

Known as: FLJ14490, MFSD2A, major facilitator superfamily domain containing 2A 
National Institutes of Health

Papers overview

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2020
2020
Biallelic MFSD2A variants associated with congenital microcephaly, developmental delay, and recognizable neuroimaging features
Major Facilitator Superfamily Domain containing 2a (MFSD2A) is an essential endothelial lipid transporter at the blood-brain… 
Review
2019
Review
2019
Effects of angiotensin-II on brain endothelial cell permeability via PPARalpha regulation of para- and trans-cellular pathways
2019
2019
Decreased Blood Level of MFSD2a as a Potential Biomarker of Alzheimer’s Disease
The protein Major Facilitator Superfamily Domain containing 2A (MFSD2a) was recently described as the primary carrier for… 
Highly Cited
2017
Highly Cited
2017
Placental MFSD2a transporter is related to decreased DHA in cord blood of women with treated gestational diabetes.
2017
2017
MFSD2A Promotes Endothelial Generation of Inflammation-Resolving Lipid Mediators and Reduces Colitis in Mice.
BACKGROUND & AIMS Alterations in signaling pathways that regulate resolution of inflammation (resolving pathways) contribute to… 
Highly Cited
2016
Highly Cited
2016
Mfsd2a Is a Transporter for the Essential ω-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development*
Eye photoreceptor membrane discs in outer rod segments are highly enriched in the visual pigment rhodopsin and the ω-3 fatty acid… 
Highly Cited
2016
Highly Cited
2016
Structural Insights into the Transport Mechanism of the Human Sodium-dependent Lysophosphatidylcholine Transporter MFSD2A*♦
Major facilitator superfamily domain containing 2A (MFSD2A) was recently characterized as a sodium-dependent… 
Highly Cited
2015
Highly Cited
2015
A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome
The major pathway by which the brain obtains essential omega-3 fatty acids from the circulation is through a sodium-dependent… 
Highly Cited
2010
Highly Cited
2010
GCM1 Regulation of the Expression of Syncytin 2 and Its Cognate Receptor MFSD2A in Human Placenta1
Syncytin 2 is a newly identified placental membrane protein with fusogenic and immunosuppressive activities. Major facilitator… 
Highly Cited
2008
Highly Cited
2008
Mfsd2a encodes a novel major facilitator superfamily domain-containing protein highly induced in brown adipose tissue during fasting and adaptive thermogenesis.
This study describes the identification of Mfsd2a (major facilitator superfamily domain-containing protein 2a), a novel mammalian… 
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