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MESDC2 gene

Known as: mesoderm development candidate 2, MESD, MESODERM DEVELOPMENT GENE 
This gene is involved in protein folding.
National Institutes of Health

Related topics

Related topics

7 relations
LDLR Chaperone MESDMESDC2/SENP1 Fusion Proteincellular response to unfolded proteinintracellular protein transport

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MESDC2 wt Allele

Papers overview

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2011
2011
MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm
Deletion of the Mesd gene region blocks gastrulation and mesoderm differentiation in mice. MESD is a chaperone for the Wnt co… 
2011
2011
Functional analysis of disease-associated polymorphism LRP5.Q89R
Purpose The canonical wingless and Int1 (Wnt) signaling pathway plays key roles in multiple biologic events. The pathway co… 
2010
2010
NMR structure note: solution structure of the core domain of MESD that is essential for proper folding of LRP5/6
2009
2009
A cell‐based Dkk1 binding assay reveals roles for extracellular domains of LRP5 in Dkk1 interaction and highlights differences between wild‐type and the high bone mass mutant LRP5(G171V)
Dkk1 is a secreted antagonist of the LRP5‐mediated Wnt signaling pathway that plays a pivotal role in bone biology. Because there… 
2009
2009
Structural and functional studies of MESD, a specialized chaperone protein of LRP5/6 in Wnt signaling
2007
2007
Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation.
Proteins of the low-density lipoprotein receptor family (LRPs) are complex, multimodular type I transmembrane receptors… 
2007
2007
The solution structure of the core of mesoderm development (MESD), a chaperone for members of the LDLR-family
Mesoderm development (MESD) is a 224 amino acid mouse protein that acts as a molecular chaperone for receptors of the low-density… 
2007
2007
A complete NMR spectral assignment of the conserved region of the MESD protein, MESD(12-155)
The low-density lipoprotein (LDL) receptor family members control diverse developmental and physiological pathways. Mesoderm… 
Highly Cited
2005
Highly Cited
2005
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
Wnt co-receptors LRP5 and LRP6 are two members of the low-density lipoprotein receptor family. Receptor-associated protein is not… 
2001
2001
Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis.
The proximal albino deletions identify several functional regions on mouse Chromosome 7 critical for differentiation of mesoderm… 
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