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MESDC2 gene

Known as: mesoderm development candidate 2, MESD, MESODERM DEVELOPMENT GENE 
This gene is involved in protein folding.
National Institutes of Health

Related topics

Related topics

7 relations
LDLR Chaperone MESDMESDC2/SENP1 Fusion Proteincellular response to unfolded proteinintracellular protein transport

Narrower (1)

MESDC2 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Artificial Intelligence Analysis of Gene Expression Data Predicted the Prognosis of Patients with Diffuse Large B-Cell Lymphoma.
OBJECTIVE We aimed to identify new biomarkers in Diffuse Large B-cell Lymphoma (DLBCL) using the deep learning technique… 
2019
2019
Autosomal Recessive Mutations in MESD Cause Osteogenesis Imperfecta.
Highly Cited
2013
Highly Cited
2013
Essential roles of grp94 in gut homeostasis via chaperoning canonical Wnt pathway
Increasing evidence points to a role for the protein quality control in the endoplasmic reticulum (ER) in maintaining intestinal… 
Review
2011
Review
2011
New insights into the roles of megalin/LRP2 and the regulation of its functional expression.
Since the discovery of the low-density lipoprotein receptor (LDLR) and its association with familial hypercholesterolemia in the… 
2011
2011
MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm
Deletion of the Mesd gene region blocks gastrulation and mesoderm differentiation in mice. MESD is a chaperone for the Wnt co… 
2010
2010
Mesd is a universal inhibitor of Wnt coreceptors LRP5 and LRP6 and blocks Wnt/beta-catenin signaling in cancer cells.
Mesd is a specialized chaperone for low-density lipoprotein receptor-related protein 5 (LRP5) and LRP6. In our previous studies… 
2007
2007
Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation.
Proteins of the low-density lipoprotein receptor family (LRPs) are complex, multimodular type I transmembrane receptors… 
Highly Cited
2005
Highly Cited
2005
Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding
Wnt co-receptors LRP5 and LRP6 are two members of the low-density lipoprotein receptor family. Receptor-associated protein is not… 
2005
2005
Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13…
Recently, we identified a patient with an infantile sacrococcygeal teratoma and a constitutional t(12;15)(q13;q25). Here, we show… 
Highly Cited
2003
Highly Cited
2003
Coaxing the LDL Receptor Family into the Fold
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