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MELAS Syndrome

Known as: Syndrome, MELAS, Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode, Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes 
A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling… 
National Institutes of Health

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Related topics

27 relations
Acidosis, LacticBilateral cataracts (disorder)Blindness, CorticalDementia

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MITOCHONDRIAL MYOPATHY AND SIDEROBLASTIC ANEMIA

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2008
Review
2008
New indications and controversies in arginine therapy.
Highly Cited
2005
Highly Cited
2005
Species and Populations of the Anopheles gambiae Complex in Cameroon with Special Emphasis on Chromosomal and Molecular Forms of Anopheles gambiae s.s.
Abstract We studied the geographical distribution of species, chromosomal, and molecular forms of the Anopheles gambiae Giles… 
Highly Cited
2004
Highly Cited
2004
Mitochondrial angiopathy in cerebral blood vessels of mitochondrial eneephalomyopathy
SummaryWe studied cerebral blood vessels of two autopsied patients with mitochondrial myopathy, encephalopathy, lactic acidosis… 
Highly Cited
1997
Highly Cited
1997
Bilateral striatal necrosis and MELAS associated with a new T3308C mutation in the mitochondrial ND1 gene.
We found a novel maternally inherited T3308C mutation in the mtDNA ND1 gene in a patient with bilateral striatal necrosis and… 
Highly Cited
1996
Highly Cited
1996
Idebenone improves cerebral mitochondrial oxidative metabolism in a patient with MELAS
We report a 36-year-old man with MELAS in whom a 5-month course of high-dose oral idebenone, a derivative of coenzyme Q10… 
Highly Cited
1994
Highly Cited
1994
Homogentisic acid is the product of MelA, which mediates melanogenesis in the marine bacterium Shewanella colwelliana D
Shewanella colwelliana D is a marine procaryote which produces a diffusible brown pigment that correlates with melA gene… 
Highly Cited
1991
Highly Cited
1991
Respiration-deficient Cells AreCausedbya Single Point Mutation intheMitochondrial tRNA-Leu(UUR)Genein Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, andStrokelike Episodes (MELAS)
Summary MELAS(mitochondrial myopathy, encephalopathy, lactic acidosis, andstrokelike episodes) isa majorsubgroup ofheterogeneous… 
Highly Cited
1991
Highly Cited
1991
Marked reduction in CSF lactate and pyruvate levels after CoQ therapy in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke‐like episodes (MELAS)
Many CoQ trials for mitochondrial encephalomyopathy are reported, however, the action of CoQ in the central nervous system is… 
Highly Cited
1988
Highly Cited
1988
Findings in muscle in complex I (NADH coenzyme Q reductase) deficiency
Thirteen of 15 patients with complex I deficiency had the multisystemic form, with strokelike episodes and other symptoms that… 
Highly Cited
1987
Highly Cited
1987
A mitochondrial encephalomyopathy with cardiomyopathy A case revealing a defect of complex I in the respiratory chain
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