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MECOM gene

Known as: MYELOID LEUKEMIA-ASSOCIATED GENE EVI1, MOUSE, HOMOLOG OF, PRDM3, MECOM 
This gene plays a role in transcriptional activation. Retroviral activation of the gene plays an important role in the translocations leading to… 
National Institutes of Health

Related topics

Related topics

9 relations
EVI1-AML1 Fusion Protein ExpressionEVI5 geneEVI5L geneEvi-1 protein

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MECOM wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Downregulation of EVI1 Expression Inhibits Cell Proliferation and Induces Apoptosis in Hilar Cholangiocarcinoma via the PTEN/AKT Signalling Pathway
Aims: Hilar cholangiocarcinoma (HCCA) is a tumour with high malignancy, low surgical resection potential, and a poor prognosis… 
2017
2017
Detection of nasopharyngeal carcinoma susceptibility with single nucleotide polymorphism analysis using next-generation sequencing technology
Nasopharyngeal carcinoma (NPC) is a head and neck cancer with high incidence in South China and East Asia. To provide a… 
2016
2016
Primary acute myeloid leukemia cells with overexpression of EVI-1 are sensitive to all-trans retinoic acid.
Enhanced expression of ecotropic viral integration site 1 (EVI-1) occurs in ∼10% of acute myeloid leukemia (AML) patients and is… 
2016
2016
Intratumoral Heterogeneity of Frameshift Mutations in MECOM Gene is Frequent in Colorectal Cancers with High Microsatellite Instability
MECOM gene, also known as EVI, encodes a transcriptional regulator involved in hematopoiesis, apoptosis, development and… 
2014
2014
Thrombopoietin/MPL signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.
Ecotropic viral integration site 1 (Evi1) is a transcription factor that is highly expressed in hematopoietic stem cells and is… 
2014
2014
Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia.
2013
2013
EVI1 splice variants modulate functional responses in ovarian cancer cells
Highly Cited
2006
Highly Cited
2006
Evi1 is a survival factor which conveys resistance to both TGFβ- and taxol-mediated cell death via PI3K/AKT
In hematopoietic cells the transforming potential of the ecotropic viral integration site 1 (Evi1) oncogene is thought to be… 
2002
2002
Large-scale identification of novel potential disease loci in mouse leukemia applying an improved strategy for cloning common virus integration sites
The identification of common virus integration sites (cVIS) in retrovirally induced tumors in mice provides a powerful strategy… 
Highly Cited
1997
Highly Cited
1997
Transcriptional Repression Mediated by the PR Domain Zinc Finger Gene RIZ *
The RIZ (G3B orMTB-Zf) zinc finger gene is structurally related to the myeloid leukemia gene, MDS1-EVI1, and the transcription… 
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