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Evi-1 protein

Known as: Ecotropic Virus Integration 1 Site Protein, MDS1 and EVI1 Complex Locus Protein EVI1, EVI1 
MDS1 and EVI1 complex locus protein EVI1 (1051 aa, ~118 kDa) is encoded by the human MECOM gene. This protein is involved in transcriptional… 
National Institutes of Health

Related topics

Related topics

10 relations
CYS2-HIS2 Zinc FingersCell NucleusDNA-Binding ProteinsGenes, Regulator

Papers overview

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2015
2015
EVI1, a target gene for amplification at 3q26, antagonizes transforming growth factor-β-mediated growth inhibition in hepatocellular carcinoma
EVI1 (ecotropic viral integration site 1) is one of the most aggressive oncogenes associated with myeloid leukemia. We… 
Review
2010
Review
2010
The role of Runx1/AML1 and Evi‐1 in the regulation of hematopoietic stem cells
Lineage‐specific transcription factors must be precisely regulated during stem cell self‐renewal and lineage commitment decisions… 
2008
2008
AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML1
The t(3;21) chromosomal translocation seen in blastic crisis of chronic myeloid leukemia and secondary leukemias results in a… 
2006
2006
Fusion of ETV 6 to MDS 1 / EVIJ as a Result of t ( 3 ; 12 ) ( q 26 ; p 13 ) in Myeloproliferative Disorders
We identifieda fusionbetweenETV6 on l2pl3 and MDSJIEVIJ on 3q26 in a t(3;12)(q26;p13)found in two casesof myeloproliferative… 
2002
2002
The t(3;21) fusion product, AML1/Evi-1 blocks AML1-induced transactivation by recruiting CtBP
AML1/Evi-1 is a chimeric protein that is derived from t(3;21), found in blastic transformation of chronic myelogenous leukemia… 
1999
1999
Mutations in the Saccharomyces cerevisiae gene SAC1 cause multiple drug sensitivity
Wild‐type yeast Saccharomyces cerevisiae are surprisingly resistant to a wide range of drugs and agents. We had previously… 
1999
1999
Evi-1 and MDS1-Evi-1 genes in pathogenesis of myelodysplastic syndromes and post-MDS acute myeloid leukemia.
OBJECTIVE To investigate expression of Evi-1 and MDS1-Evi-1 genes in myelodysplastic syndromes (MDS) and post-MDS acute myeloid… 
1996
1996
Rearrangement of the AML1/CBFA2 gene in myeloid leukemia with the 3;21 translocation: expression of co-existing multiple chimeric genes with similar functions as transcriptional repressors, but with…
Several recurring chromosomal translocations involve the AML1 gene at 21q22 in myeloid leukemias resulting in fusion mRNAs and… 
1992
1992
Analysis of proviruses integrated in Fli-1 and Evi-1 regions in Cas-Br-E MuLV-induced non-T-, non-B-cell leukemias.
Highly Cited
1989
Highly Cited
1989
Retroviral insertions in the CB-1/Fim-3 common site of integration activate expression of the Evi-1 gene.
A common retroviral integration site (CB-1) was identified in two IL-3-dependent myeloid leukemia cell lines (DA-3, DA-34). The… 
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