MDA5

 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
MDA5 is an essential intracellular sensor for several viruses, including picornaviruses, and elicits antiviral interferon (IFN… (More)
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Highly Cited
2013
Highly Cited
2013
RIG-I and MDA5 have emerged as key cytosolic sensors for the detection of RNA viruses and lead to antiviral interferon (IFN… (More)
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Highly Cited
2012
Highly Cited
2012
Melanoma differentiation-associated gene-5 (MDA5) detects viral double-stranded RNA in the cytoplasm. RNA binding induces MDA5 to… (More)
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Highly Cited
2011
Highly Cited
2011
Dengue virus (DV) infection is one of the most common mosquito-borne viral diseases in the world. The innate immune system is… (More)
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Highly Cited
2011
Highly Cited
2011
MDA5, an RIG-I-like helicase, is a conserved cytoplasmic viral RNA sensor, which recognizes dsRNA from a wide-range of viruses in… (More)
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Highly Cited
2009
Highly Cited
2009
Recognition of virus presence via RIG-I (retinoic acid inducible gene I) and/or MDA5 (melanoma differentiation-associated protein… (More)
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Highly Cited
2009
Highly Cited
2009
Intracellular pattern recognition receptors MDA5, RIG-I, and LGP2 are essential components of the cellular response to virus… (More)
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Highly Cited
2008
Highly Cited
2008
RIG-I and MDA5, two related pathogen recognition receptors (PRRs), are known to be required for sensing various RNA viruses. Here… (More)
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Highly Cited
2006
Highly Cited
2006
The innate immune system senses viral infection by recognizing a variety of viral components (including double-stranded (ds)RNA… (More)
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Review
2006
Review
2006
The innate immune system relies on its capacity to rapidly detect invading pathogenic microbes as foreign and eliminate them… (More)
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