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MAP3K7 gene

Known as: MAP3K7, TGF-BETA-ACTIVATED KINASE 1, TAK1a 
This gene plays a role in apoptosis, transcription and the cellular response to stress.
National Institutes of Health

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Related topics

9 relations
ApoptosisMAP kinase kinase kinase 7MAP3K7 protein, humanPhosphorylation

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MAP3K7 wt Allele

Papers overview

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Highly Cited
2020
Highly Cited
2020
AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System.
Highly Cited
2016
Highly Cited
2016
Induction of Macrophage Function in Human THP-1 Cells Is Associated with Rewiring of MAPK Signaling and Activation of MAP3K7 (TAK1) Protein Kinase
Macrophages represent the primary human host response to pathogen infection and link the immediate defense to the adaptive immune… 
Highly Cited
2016
Highly Cited
2016
Mutations in MAP3K7 that Alter the Activity of the TAK1 Signaling Complex Cause Frontometaphyseal Dysplasia.
2016
2016
Heterozygous Mutations in MAP3K7, Encoding TGF-β-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome.
Highly Cited
2015
Highly Cited
2015
Dexamethasone-induced apoptosis of osteocytic and osteoblastic cells is mediated by TAK1 activation.
Highly Cited
2015
Highly Cited
2015
MiR-377 targets E2F3 and alters the NF-kB signaling pathway through MAP3K7 in malignant melanoma
The incidence of cutaneous malignant melanoma continues to rise, and once the disease metastasizes it is almost inevitably fatal… 
Review
2014
Review
2014
TAK1 regulates hepatic cell survival and carcinogenesis
TGF-β-activated kinase 1 (TAK1 or MAP3K7) is an intracellular hub molecule that regulates both nuclear factor-κB (NF-κB) and… 
Highly Cited
2009
Highly Cited
2009
Lysine 63-linked Polyubiquitination of TAK1 at Lysine 158 Is Required for Tumor Necrosis Factor α- and Interleukin-1β-induced IKK/NF-κB and JNK/AP-1 Activation*
Transforming growth factor-β-activated kinase 1 (TAK1) plays an essential role in the tumor necrosis factor α (TNFα)- and… 
Highly Cited
2007
Highly Cited
2007
Deletion of a Small Consensus Region at 6q15, Including the MAP3K7 Gene, Is Significantly Associated with High-Grade Prostate Cancers
Purpose: Chromosome 6q14-21 is commonly deleted in prostate cancers, occurring in ∼22% of all tumors and ∼40% of metastatic… 
Highly Cited
2005
Highly Cited
2005
TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation.
Receptor-interacting protein (RIP) plays a critical role in tumor necrosis factor-alpha (TNF-alpha)-induced IkappaB kinase (IKK… 
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