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MAP3K7 gene

Known as: MAP3K7, TGF-BETA-ACTIVATED KINASE 1, TAK1a 
This gene plays a role in apoptosis, transcription and the cellular response to stress.
National Institutes of Health

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ApoptosisMAP kinase kinase kinase 7MAP3K7 protein, humanPhosphorylation

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MAP3K7 wt Allele

Papers overview

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2020
2020
A novel variant in MAP3K7 associated with an expanded cardiospondylocarpofacial syndrome phenotype
The transforming growth factor-β-activated kinase 1 (TAK1) encoded by mitogen-activated protein kinase kinase kinase 7 (MAP3K7… 
2018
2018
A novel MAP3K7 splice mutation causes cardiospondylocarpofacial syndrome with features of hereditary connective tissue disorder
Heterozygous variants in MAP3K7, encoding the transforming growth factor-β-activated kinase 1 (TAK1), are associated with the… 
2018
2018
EDHS‐206, an Exquisitely Selective Inhibitor of TAK1, Targets Pro Survival TNFα‐Dependent Signaling, Inducing Apoptosis in Rheumatoid Arthritis and Breast Cancer Models
2013
2013
Kinase-Independent Feedback of the TAK1/TAB1 Complex on BCL10 Turnover and NF-κB Activation
ABSTRACT Antigen receptors activate pathways that control cell survival, proliferation, and differentiation. Two important… 
2012
2012
Abstract LB-427: TAK1 (MAP3K7) inhibition promotes apoptosis in KRAS dependent colon cancers
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Colon cancers frequently harbor KRAS mutations… 
2008
2008
Generation of a conditional mutant allele for Tab1 in mouse
TAK1 binding protein 1 (TAB1) binds and induces autophosphorylation of TGF‐β activating kinase (TAK1). TAK1, a mitogen‐activated… 
2008
2008
Discovery of small molecule inhibitors of MAP3K7 (TAK1) that induce apoptosis of distinct subtypes of B-cell lymphoma cells
1292 Despite recent advances with novel therapeutics, there is a high level of unmet need in B-cell malignancies. As part of our… 
2007
2007
JNK‐ and Rac1‐dependent induction of immediate early gene pip92 suppresses neuronal differentiation
The immediate early gene pip92 is rapidly and transiently induced by serum, basic fibroblast growth factor (bFGF), nerve growth… 
2007
2007
Regulation and targets of TAK1 MAPKKK in IL-1 and TGF-β signaling pathways
1995
1995
Cloning of the gene encoding the murine orphan receptor TAK1 and cell-type-specific expression in testis.
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