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MAP3K5 wt Allele

Known as: MEKK 5, MAPKKK5, ASK-1 
Human MAP3K5 wild-type allele is located in the vicinity of 6q22.33 and is approximately 235 kb in length. This allele, which encodes mitogen… 
National Institutes of Health

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Related topics

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MAPK Signaling PathwayNeurotrophin Signaling PathwayPhosphorylationPositive Regulation of Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Apoptosis signal‐regulating kinase 1 in peptidoglycan‐induced COX‐2 expression in macrophages
In this study, we investigated the role of ASK1 in PGN‐induced C/EBPβ activation and COX‐2 expression in RAW 264.7 macrophages… 
2009
2009
Reciprocal Negative Regulation of PDK1 and ASK1 Signaling by Direct Interaction and Phosphorylation*
Cell survival and death-inducing signals are tightly associated with each other, and the decision as to whether a cell survives… 
2007
2007
Important role of apoptosis signal-regulating kinase 1 in ischemic acute kidney injury.
Highly Cited
2005
Highly Cited
2005
Tumor Necrosis Factor α-induced Desumoylation and Cytoplasmic Translocation of Homeodomain-interacting Protein Kinase 1 Are Critical for Apoptosis Signal-regulating Kinase 1-JNK/p38 Activation*
The apoptosis signal-regulating kinase 1 (ASK1)-JNK/p38 signaling pathway is pivotal component in cell apoptosis and can be… 
2004
2004
Binding activity of H-Ras is necessary for in vivo inhibition of ASK1 activity
ABSTRACTH-Ras is well known as one of the essential components of Ras/Raf/MEK/ERK cascade, which is a critical prosurvival… 
Highly Cited
2003
Highly Cited
2003
Role of the ASK1-SEK1-JNK1-HIPK1 Signal in Daxx Trafficking and ASK1 Oligomerization*
Overexpression of JNK binding domain inhibited glucose deprivation-induced JNK1 activation, relocalization of Daxx from the… 
2003
2003
The Ret Finger Protein Induces Apoptosis via Its RING Finger-B Box-Coiled-coil Motif*
The Ret finger protein (RFP) is a member of the tripartite motif family, which is characterized by a conserved RING finger, a B… 
2002
2002
Lymphotoxin beta receptor induces interleukin 8 gene expression via NF-kappaB and AP-1 activation.
The human lymphotoxin beta receptor (LTbetaR), a member of the tumor necrosis factor (TNF) receptor superfamily, is essential for… 
2001
2001
ASK1-signaling promotes c-Myc protein stability during apoptosis.
We previously reported that JNK is involved in the regulation of c-Myc-mediated apoptosis triggered by UV irradiation and… 
Highly Cited
1999
Highly Cited
1999
Human DU145 prostate cancer cells overexpressing mitogen-activated protein kinase phosphatase-1 are resistant to Fas ligand-induced mitochondrial perturbations and cellular apoptosis
Recent studies have suggested that MAP kinase phosphatase 1 (MKP-1) is overexpressed in prostate cancer. To evaluate the role of… 
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