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MAP3K5 wt Allele

Known as: MEKK 5, MAPKKK5, ASK-1 
Human MAP3K5 wild-type allele is located in the vicinity of 6q22.33 and is approximately 235 kb in length. This allele, which encodes mitogen… 
National Institutes of Health

Related topics

Related topics

7 relations
MAPK Signaling PathwayNeurotrophin Signaling PathwayPhosphorylationPositive Regulation of Apoptosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Atmospheric gas plasma–induced ROS production activates TNF-ASK1 pathway for the induction of melanoma cancer cell apoptosis
Atmospheric gas plasmas (AGPs) up-regulate intracellular ROS levels and induce apoptosis in melanoma cells. Evidence for TNF… 
Review
2009
Review
2009
Ghrelin in Central Neurons
Ghrelin, an orexigenic peptide synthesized by endocrine cells of the gastric mucosa, is released in the bloodstream in response… 
Highly Cited
2008
Highly Cited
2008
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
BACKGROUND & AIMS Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver failure. C-jun N-terminal kinase… 
Highly Cited
2006
Highly Cited
2006
Thioredoxin‐ASK1 complex levels regulate ROS‐mediated p38 MAPK pathway activity in livers of aged and long‐lived Snell dwarf mice
We have proposed that the age‐associated increase of reactive oxygen species (ROS) by electron transport chain (ETC) dysfunction… 
Highly Cited
2006
Highly Cited
2006
Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2–ASK1 signals
Human glutathione S-transferase P1-1 (GSTP1-1) is an ubiquitously expressed protein that plays an important role in the… 
Highly Cited
2005
Highly Cited
2005
Recruitment of Tumor Necrosis Factor Receptor-associated Factor Family Proteins to Apoptosis Signal-regulating Kinase 1 Signalosome Is Essential for Oxidative Stress-induced Cell Death*
Apoptosis signal-regulating kinase 1 (ASK1) plays a pivotal role in oxidative stress-induced cell death. Reactive oxygen species… 
Highly Cited
2003
Highly Cited
2003
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling
Left ventricular remodeling that occurs after myocardial infarction (MI) and pressure overload is generally accepted as a… 
Highly Cited
2002
Highly Cited
2002
β-Arrestin2 Is Critically Involved in CXCR4-mediated Chemotaxis, and This Is Mediated by Its Enhancement of p38 MAPK Activation*
Chemotaxis mediated by chemokine receptors such as CXCR4 plays a key role in lymphocyte homing and hematopoiesis as well as in… 
Review
2002
Review
2002
Physiological roles of ASK1-mediated signal transduction in oxidative stress- and endoplasmic reticulum stress-induced apoptosis: advanced findings from ASK1 knockout mice.
Apoptosis, a molecularly regulated form of cell death, is essential for the normal functioning and homeostasis of most… 
Highly Cited
2001
Highly Cited
2001
Glutathione S-Transferase Mu Modulates the Stress-activated Signals by Suppressing Apoptosis Signal-regulating Kinase 1*
Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase that can activate the c-Jun N… 
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