MAP3K5 wt Allele

Known as: MEKK 5, MAPKKK5, ASK-1 
Human MAP3K5 wild-type allele is located in the vicinity of 6q22.33 and is approximately 235 kb in length. This allele, which encodes mitogen… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2017
010203019972017

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Chronic alcoholism leads to the onset and progression of alcoholic cardiomyopathy through toxic mechanisms of ethanol… (More)
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Highly Cited
2004
Highly Cited
2004
Many intracellular signalling events are accompanied by generation of reactive oxygen species in cells. Oxidation of protein… (More)
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Highly Cited
2003
Highly Cited
2003
Cisplatin and its analogues have been widely used for treatment of human cancer. However, most patients eventually develop… (More)
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Highly Cited
2001
Highly Cited
2001
Apoptosis signal-regulating kinase (ASK) 1 is activated in response to various cytotoxic stresses including TNF, Fas and reactive… (More)
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Highly Cited
2000
Highly Cited
2000
As a result of identifying the regulatory proteins of thioredoxin (TRX), a murine homologue for human vitamin D3 up-regulated… (More)
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Highly Cited
2000
Highly Cited
2000
Antioxidant response element (ARE) regulates the induction of a number of cellular antioxidant and detoxifying enzymes. However… (More)
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Highly Cited
2000
Highly Cited
2000
ASK1 activates JNK and p38 mitogen-activated protein kinases and constitutes a pivotal signaling pathway in cytokine- and stress… (More)
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Highly Cited
1998
Highly Cited
1998
Tumor necrosis factor (TNF)-induced activation of the c-jun N-terminal kinase (JNK, also known as SAPK; stress-activated protein… (More)
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Highly Cited
1998
Highly Cited
1998
Reactive oxygen species (ROS) have been implicated in the induction of apoptosis by tumor necrosis factor-alpha (TNFalpha) and… (More)
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Highly Cited
1997
Highly Cited
1997
Mitogen-activated protein (MAP) kinase cascades are activated in response to various extracellular stimuli, including growth… (More)
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