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MAP2K6 gene

Known as: MAP2K6, MEK6, MKK6 
This gene plays a role in apoptotic regulation by utilizing the MAP kinase signal transduction pathway.
National Institutes of Health

Related topics

Related topics

12 relations
ApoptosisCell Death Signaling ProcessCell SurvivalMAP Kinase Kinase 6

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MAP2K6 wt Allele

Papers overview

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Highly Cited
2000
Highly Cited
2000
A Role for the p38 MAP Kinase Pathway in the Nuclear Shuttling of NFATp*
Calcium signals lead to the translocation of nuclear factor of activated T cells (NFAT) from the cytoplasm to the nucleus. This… 
Highly Cited
1999
Highly Cited
1999
Involvement of the p38 Mitogen-activated Protein Kinase Pathway in Transforming Growth Factor-β-induced Gene Expression*
Transforming growth factor-β (TGF-β)-activated kinase 1 (TAK1), a member of the mitogen-activated protein kinase kinase kinase… 
Highly Cited
1999
Highly Cited
1999
Activation of p38 Mitogen-activated Protein Kinase by PYK2/Related Adhesion Focal Tyrosine Kinase-dependent Mechanism*
The stress-activated p38 mitogen-activated protein kinase (p38 MAPK), a member of the subgroup of mammalian kinases, appears to… 
Highly Cited
1998
Highly Cited
1998
MKK6 Activates Myocardial Cell NF-κB and Inhibits Apoptosis in a p38 Mitogen-activated Protein Kinase-dependent Manner*
In cardiac myocytes the stimulation of p38 mitogen-activated protein kinase activates a hypertrophic growth program and the… 
Highly Cited
1998
Highly Cited
1998
T Lymphocyte Activation Signals for Interleukin-2 Production Involve Activation of MKK6-p38 and MKK7-SAPK/JNK Signaling Pathways Sensitive to Cyclosporin A*
p38/CSBP, a subgroup member of mitogen-activated protein kinase (MAPK) superfamily molecules, is known to be activated by… 
Highly Cited
1997
Highly Cited
1997
Activation of stress‐activated protein kinase‐3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
Stress‐activated protein kinase‐3 (SAPK3), a recently described MAP kinase family member with a widespread tissue distribution… 
Highly Cited
1997
Highly Cited
1997
Activation of the novel stress‐activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
A cDNA was cloned that encodes human stress‐activated protein kinase‐4 (SAPK4), a novel MAP kinase family member whose amino acid… 
Highly Cited
1997
Highly Cited
1997
A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress‐induced activation of the p38 and JNK pathways
A human homolog of the yeast Ssk2 and Ssk22 mitogen‐activated protein kinase kinase kinases (MAPKKK) was cloned by functional… 
Highly Cited
1996
Highly Cited
1996
Characterization of the Structure and Function of a Novel MAP Kinase Kinase (MKK6) (*)
Mitogen-activated protein (MAP) kinases require dual phosphorylation on threonine and tyrosine residues in order to gain… 
Highly Cited
1996
Highly Cited
1996
Cloning and Characterization of MEK6, a Novel Member of the Mitogen-activated Protein Kinase Kinase Cascade (*)
Mitogen-activated protein kinases are members of a conserved cascade of kinases involved in many signal transduction pathways… 
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