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MAP2K6 gene

Known as: MAP2K6, MEK6, MKK6 
This gene plays a role in apoptotic regulation by utilizing the MAP kinase signal transduction pathway.
National Institutes of Health

Related topics

Related topics

12 relations
ApoptosisCell Death Signaling ProcessCell SurvivalMAP Kinase Kinase 6

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MAP2K6 wt Allele

Papers overview

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2018
2018
Quantitative proteome analysis identifies MAP2K6 as potential regulator of LIFR-induced radioresistance in nasopharyngeal carcinoma cells.
2014
2014
Involvement of Potato (Solanum tuberosum L.) MKK6 in Response to Potato virus Y
Mitogen-activated protein kinase (MAPK) cascades have crucial roles in the regulation of plant development and in plant responses… 
2012
2012
Crystal structure of non-phosphorylated MAP2K6 in a putative auto-inhibition state.
Mitogen-activated protein kinase kinase 6 (MAP2K6) plays a crucial role in the p38 MAP kinase signal cascade that regulates… 
2010
2010
Role of the 18:1 Lysophosphatidic Acid–Ovarian Cancer Immunoreactive Antigen Domain Containing 1 (OCIAD1)–Integrin Axis in Generating Late-Stage Ovarian Cancer
Chemotherapy resistance in ovarian cancer remains an unsolved problem in caring for women with this disease. We now show that… 
2010
2010
Mechanism of oxidative stress-induced ASK1-catalyzed MKK6 phosphorylation.
Apoptosis signal-regulating kinase 1 (ASK1) is a serine/threonine kinase that responds to a plethora of stress-inducing signals… 
Highly Cited
2004
Highly Cited
2004
p38 MAPK Activation Selectively Induces Cell Death in K-ras-mutated Human Colon Cancer Cells through Regulation of Vitamin D Receptor*
ras is the most characterized oncogene in human cancer, and yet there are no effective therapeutics to selectively target this… 
2004
2004
Lack of p38 MAP Kinase Activation in TRAIL-Resistant Cells is Not Related to the Resistance to TRAIL-Mediated Cell Death
Activation of MAP kinases is involved in various cellular processes, including immunoregulation, inflammation, cell growth, cell… 
2003
2003
Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase.
p38 mitogen-activated protein (MAP) kinases play an important role in the regulation of cellular responses to all kinds of… 
2003
2003
Regulation of a mitogen-activated protein kinase kinase kinase, MLTK by PKN.
PKNalpha is a fatty acid- and Rho-activated serine/threonine protein kinase having a catalytic domain homologous to members of… 
Highly Cited
1999
Highly Cited
1999
c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation.
c-Abl is a ubiquitously expressed protein tyrosine kinase activated by DNA damage and implicated in two responses: cell cycle… 
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