MAP2K1 gene

Known as: Mitogen-Activated Protein Kinase Kinase 1 Gene, MKK1, PRKMK1 
This gene plays a role in signal transduction and regulation of transcription. It is also involved in cell differentiation, growth and proliferation.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder characterized by lesions composed of pathological CD207… (More)
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Highly Cited
2014
Highly Cited
2014
Langerhans cell histiocytosis (LCH) represents a clonal proliferation of Langerhans cells. BRAF V600E mutations have been… (More)
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2012
2012
The scirrhous subtype of gastric cancer is a highly infiltrative tumor with a poor outcome. To identify a transforming gene in… (More)
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Highly Cited
2011
Highly Cited
2011
We performed exome sequencing to detect somatic mutations in protein-coding regions in seven melanoma cell lines and donor… (More)
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2007
2007
BACKGROUND Among gynecologic cancers, ovarian cancer is the second most common and has the highest death rate. Cancer is a… (More)
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2004
2004
We performed a functional genomic analysis to study the effect of epicatechin and polyphenolic cocoa extract in the human colon… (More)
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2002
2002
The Rit, Rin, and Ric proteins comprise a distinct and evolutionarily conserved subfamily of the Ras-like small G-proteins… (More)
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1998
1998
The synthesis of cyclin D1 and its assembly with cyclin-dependent kinase 4 (CDK4) to form an active complex is a rate-limiting… (More)
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1996
1996
Both mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 function downstream of the proto-oncogene product Raf in… (More)
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1996
1996
Cell proliferation requires the co-ordinate triggering of several protein kinases of Ser/Thr specificity such as p70 S6 kinase… (More)
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