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MAP2K1 gene

Known as: Mitogen-Activated Protein Kinase Kinase 1 Gene, MKK1, PRKMK1 
This gene plays a role in signal transduction and regulation of transcription. It is also involved in cell differentiation, growth and proliferation.
National Institutes of Health

Related topics

Related topics

8 relations
Cell Differentiation processCell ProliferationMAP Kinase Kinase 1MAP2K1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Trametinib for the treatment of IGHV4-34, MAP2K1-mutant variant hairy cell leukemia
Leslie A. Andritsos , Nicole R. Grieselhuber , Mirela Anghelina, Kerry A. Rogers, Sameek Roychowdhury, Julie W. Reeser, Cynthia D… 
Review
2017
Review
2017
ROS1 Fusions Rarely Overlap with Other Oncogenic Drivers in Non–Small Cell Lung Cancer
2015
2015
NOTCH1, TP53, and MAP2K1 Mutations in Splenic Diffuse Red Pulp Small B-cell Lymphoma Are Associated With Progressive Disease
Splenic diffuse red pulp small B-cell lymphoma (SDRPL) is considered an indolent neoplasm and its pathogenesis is not well known… 
Highly Cited
2010
Highly Cited
2010
MicroRNA-34a Inhibits Cell Proliferation by Repressing Mitogen-Activated Protein Kinase Kinase 1 during Megakaryocytic Differentiation of K562 Cells
Phorbol 12-myristate 13-acetate (PMA) induces megakaryocytic differentiation of the human chronic myelocytic leukemia cell line… 
Review
2009
Review
2009
Spectrum of MEK1 and MEK2 gene mutations in cardio-facio-cutaneous syndrome and genotype–phenotype correlations
Cardio-facio-cutaneous syndrome (CFCS) is a rare disease characterized by mental retardation, facial dysmorphisms, ectodermal… 
Highly Cited
2004
Highly Cited
2004
Epicatechin and a cocoa polyphenolic extract modulate gene expression in human Caco-2 cells.
We performed a functional genomic analysis to study the effect of epicatechin and polyphenolic cocoa extract in the human colon… 
Highly Cited
2002
Highly Cited
2002
Induction of Neurite Extension and Survival in Pheochromocytoma Cells by the Rit GTPase*
The Rit, Rin, and Ric proteins comprise a distinct and evolutionarily conserved subfamily of the Ras-like small G-proteins… 
Highly Cited
1996
Highly Cited
1996
Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses.
Both mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 function downstream of the proto-oncogene product Raf in… 
Highly Cited
1996
Highly Cited
1996
Oncogenic Raf-1 Activates p70 S6 Kinase via a Mitogen-activated Protein Kinase-independent Pathway*
Cell proliferation requires the co-ordinate triggering of several protein kinases of Ser/Thr specificity such as p70 S6 kinase… 
1995
1995
Toward a cDNA map of the human genome.
Advances in the Human Genome Project are shaping the strategies for identifying the 50,000-100,000 human genes. High-resolution… 
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