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MAP2K1 gene

Known as: Mitogen-Activated Protein Kinase Kinase 1 Gene, MKK1, PRKMK1 
This gene plays a role in signal transduction and regulation of transcription. It is also involved in cell differentiation, growth and proliferation.
National Institutes of Health

Related topics

Related topics

8 relations
Cell Differentiation processCell ProliferationMAP Kinase Kinase 1MAP2K1 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
BRAFV600E and MAP2K1 mutations in Langerhans cell histiocytosis occur predominantly in children
Langerhans cell histiocytosis (LCH) is a proliferative disease of CD1a+/CD207+ dendritic cells. Recurrent BRAFV600E and MAP2K1… 
2017
2017
Mutations of MAP 2 K 1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation Running title : Genetics of pediatric-type follicular lymphoma
Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University… 
2017
2017
INTEGRATIVE MUTATIONAL ANALYSIS OF PEDIATRIC‐TYPE FOLLICULAR LYMPHOMA REVEALS TNFRSF14 AND MAP2K1 AS THE MOST FREQUENTLY MUTATED GENES
Introduction: Nodal marginal zone lymphoma (NMZL) is a rare form of small B‐cell lymphoma. NMZL has no disease‐defining phenotype… 
2016
2016
Mapping protein function with CRISPR/Cas9-mediated mutagenesis
CRISPR/Cas9 screening has proven to be a versatile tool for genomics research. We describe a CRISPR/Cas9-mediated approach to… 
2016
2016
Trametinib for the Treatment of IGHV4-34, MAP2K1 Mutant Variant Hairy Cell Leukemia
Background: Mutations of MAP2K1, which encodes MEK1, have been identified in up to half of patients with variant Hairy Cell… 
2014
2014
Abstract 2232: Next generation sequencing of the EGFR signaling pathway in colon cancer tumors from Chilean patients
Introduction: The Epidermal Growth Factor Receptor (EGFR) signaling pathway regulates key cell functions like proliferation and… 
2010
2010
MicroRNA-34 a Inhibits Cell Proliferation by Repressing Mitogen-Activated Protein Kinase Kinase 1 during Megakaryocytic Differentiation of K 562 Cells
Phorbol 12-myristate 13-acetate (PMA) induces megakaryocytic differentiation of the human chronic myelocytic leukemia cell line… 
2008
2008
MEK1/2 Induces STAT5-Mediated Germline Transcription of the TCRγ Locus in Response to IL-7R Signaling1
The IL-7R plays an essential role in γδ T cell development by inducing V-J recombination of the TCRγ locus through STAT5… 
2004
2004
Nutrient – Gene Interactions Epicatechin and a Cocoa Polyphenolic Extract Modulate Gene Expression in Human Caco-2 Cells 1
We performed a functional genomic analysis to study the effect of epicatechin and polyphenolic cocoa extract in the human colon… 
1995
1995
Activation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factor.
Mitogen-activated protein kinase kinase (MAPKK) is a dual-specificity protein kinase which phosphorylates and activates mitogen… 
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