MAP2K1 gene

Known as: Mitogen-Activated Protein Kinase Kinase 1 Gene, MKK1, PRKMK1 
This gene plays a role in signal transduction and regulation of transcription. It is also involved in cell differentiation, growth and proliferation.
National Institutes of Health

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Cell Differentiation processCell ProliferationMAP Kinase Kinase 1MAP2K1 protein, human
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Papers overview

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Highly Cited
2014
Highly Cited
2014
Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis.
Langerhans cell histiocytosis (LCH) is a myeloproliferative disorder characterized by lesions composed of pathological CD207… (More)
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Highly Cited
2014
Highly Cited
2014
High prevalence of somatic MAP2K1 mutations in BRAF V600E-negative Langerhans cell histiocytosis.
Langerhans cell histiocytosis (LCH) represents a clonal proliferation of Langerhans cells. BRAF V600E mutations have been… (More)
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2012
2012
Oncogenic MAP2K1 mutations in human epithelial tumors.
The scirrhous subtype of gastric cancer is a highly infiltrative tumor with a poor outcome. To identify a transforming gene in… (More)
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Highly Cited
2011
Highly Cited
2011
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma
We performed exome sequencing to detect somatic mutations in protein-coding regions in seven melanoma cell lines and donor… (More)
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2007
2007
Mutation Analysis of BRAF, MEK1 and MEK2 in 15 Ovarian Cancer Cell Lines: Implications for Therapy
BACKGROUND Among gynecologic cancers, ovarian cancer is the second most common and has the highest death rate. Cancer is a… (More)
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2004
2004
Epicatechin and a cocoa polyphenolic extract modulate gene expression in human Caco-2 cells.
We performed a functional genomic analysis to study the effect of epicatechin and polyphenolic cocoa extract in the human colon… (More)
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2002
2002
Induction of neurite extension and survival in pheochromocytoma cells by the Rit GTPase.
The Rit, Rin, and Ric proteins comprise a distinct and evolutionarily conserved subfamily of the Ras-like small G-proteins… (More)
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1998
1998
Regulation of exit from quiescence by p27 and cyclin D1-CDK4.
The synthesis of cyclin D1 and its assembly with cyclin-dependent kinase 4 (CDK4) to form an active complex is a rate-limiting… (More)
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1996
1996
Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses.
Both mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 function downstream of the proto-oncogene product Raf in… (More)
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1996
1996
Oncogenic Raf-1 activates p70 S6 kinase via a mitogen-activated protein kinase-independent pathway.
Cell proliferation requires the co-ordinate triggering of several protein kinases of Ser/Thr specificity such as p70 S6 kinase… (More)
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