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MAP2K1 gene
Known as:
Mitogen-Activated Protein Kinase Kinase 1 Gene
, MKK1
, PRKMK1
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This gene plays a role in signal transduction and regulation of transcription. It is also involved in cell differentiation, growth and proliferation.
National Institutes of Health
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Related topics
Related topics
8 relations
Cell Differentiation process
Cell Proliferation
MAP Kinase Kinase 1
MAP2K1 protein, human
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
BRAFV600E and MAP2K1 mutations in Langerhans cell histiocytosis occur predominantly in children
K. Zeng
,
K. Ohshima
,
+9 authors
Ying Guo
Hematological Oncology
2017
Corpus ID: 33874555
Langerhans cell histiocytosis (LCH) is a proliferative disease of CD1a+/CD207+ dendritic cells. Recurrent BRAFV600E and MAP2K1…
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2017
2017
Mutations of MAP 2 K 1 are frequent in pediatric-type follicular lymphoma and result in ERK pathway activation Running title : Genetics of pediatric-type follicular lymphoma
J. Schmidt
,
J. Ramis-Zaldivar
,
+20 authors
L. Quintanilla‐Martinez
2017
Corpus ID: 207882000
Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University…
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2017
2017
INTEGRATIVE MUTATIONAL ANALYSIS OF PEDIATRIC‐TYPE FOLLICULAR LYMPHOMA REVEALS TNFRSF14 AND MAP2K1 AS THE MOST FREQUENTLY MUTATED GENES
J. Schmidt
,
J. Ramis-Zaldivar
,
+11 authors
L. Quintanilla‐Martinez
2017
Corpus ID: 80508783
Introduction: Nodal marginal zone lymphoma (NMZL) is a rare form of small B‐cell lymphoma. NMZL has no disease‐defining phenotype…
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2016
2016
Mapping protein function with CRISPR/Cas9-mediated mutagenesis
Katherine F. Donovan
,
Mudra Hegde
,
+4 authors
John G Doench
bioRxiv
2016
Corpus ID: 14002326
CRISPR/Cas9 screening has proven to be a versatile tool for genomics research. We describe a CRISPR/Cas9-mediated approach to…
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2016
2016
Trametinib for the Treatment of IGHV4-34, MAP2K1 Mutant Variant Hairy Cell Leukemia
L. Andritsos
,
M. Anghelina
,
+11 authors
M. Grever
2016
Corpus ID: 208348014
Background: Mutations of MAP2K1, which encodes MEK1, have been identified in up to half of patients with variant Hairy Cell…
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2014
2014
Abstract 2232: Next generation sequencing of the EGFR signaling pathway in colon cancer tumors from Chilean patients
K. Álvarez
,
P. Orellana
,
+8 authors
P. Carvallo
2014
Corpus ID: 72878681
Introduction: The Epidermal Growth Factor Receptor (EGFR) signaling pathway regulates key cell functions like proliferation and…
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2010
2010
MicroRNA-34 a Inhibits Cell Proliferation by Repressing Mitogen-Activated Protein Kinase Kinase 1 during Megakaryocytic Differentiation of K 562 Cells
A. Ichimura
,
Y. Ruike
,
Kazuya Terasawa
,
K. Shimizu
,
G. Tsujimoto
2010
Corpus ID: 34275053
Phorbol 12-myristate 13-acetate (PMA) induces megakaryocytic differentiation of the human chronic myelocytic leukemia cell line…
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2008
2008
MEK1/2 Induces STAT5-Mediated Germline Transcription of the TCRγ Locus in Response to IL-7R Signaling1
K. Maki
,
K. Ikuta
Journal of Immunology
2008
Corpus ID: 26012728
The IL-7R plays an essential role in γδ T cell development by inducing V-J recombination of the TCRγ locus through STAT5…
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2004
2004
Nutrient – Gene Interactions Epicatechin and a Cocoa Polyphenolic Extract Modulate Gene Expression in Human Caco-2 Cells 1
V. Noé
,
S. Peñuelas
,
R. Lamuela-Raventós
,
Joan Permanyer
,
C. Ciudad
,
M. Izquierdo-Pulido
2004
Corpus ID: 86859242
We performed a functional genomic analysis to study the effect of epicatechin and polyphenolic cocoa extract in the human colon…
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1995
1995
Activation of two isoforms of mitogen-activated protein kinase kinase in response to epidermal growth factor and nerve growth factor.
T. Moriguchi
,
Yukiko Gotoh
,
Eisuke Nishida
European Journal of Biochemistry
1995
Corpus ID: 21417951
Mitogen-activated protein kinase kinase (MAPKK) is a dual-specificity protein kinase which phosphorylates and activates mitogen…
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