FAQ

MAP Kinase Kinase 1

Known as: MEK1 Protein Kinase, MKK 1 Protein Kinase, MAPK Kinase 1 
An abundant 43-kDa mitogen-activated protein kinase kinase subtype with specificity for MITOGEN-ACTIVATED PROTEIN KINASE 1 and MITOGEN-ACTIVATED… (More)
National Institutes of Health

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Topic mentions per year

1995-2017
01219952017

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10 relations
In BloodMAP Kinase Kinase Kinase 1MAP2K1 geneProcess of secretion
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MAP2K1 protein, human

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
MAP Kinase Kinase 1
physiological aspects
In Blood
chemical synthesis
MAP2K1 protein, human
standards characteristics

Papers overview

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Review
2014
Review
2014
Detecting the spectrum of multigene mutations in non-small cell lung cancer by Snapshot assay
As molecular targets continue to be identified and more targeted inhibitors are developed for personalized treatment of non-small… (More)
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Highly Cited
2008
Highly Cited
2008
Presynaptic alpha 7- and beta 2-containing nicotinic acetylcholine receptors modulate excitatory amino acid release from rat prefrontal cortex nerve terminals via distinct cellular mechanisms.
Nicotine can enhance working memory and attention. Activation of both alpha7 and beta2(*) nicotinic acetylcholine receptors… (More)
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Highly Cited
2008
Highly Cited
2008
The novel adipocytokine visfatin exerts direct cardioprotective effects
Visfatin is an adipocytokine capable of mimicking the glucose-lowering effects of insulin and activating the pro-survival kinases… (More)
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2006
2006
Mitogen-activated protein kinase pathway regulates cell proliferation in venous ulcer fibroblasts.
Venous ulcer fibroblasts have been demonstrated to have low growth rates in response to platelet-derived growth factor (PDGF… (More)
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2005
2005
ERK1/2 is a negative regulator of homeodomain protein Arix/Phox2a.
The homeodomain protein Arix/Phox2a plays a role in the development and maintenance of the noradrenergic cell type by regulating… (More)
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2001
2001
Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression.
Chronic cocaine use elicits changes in the pattern of gene expression within reinforcement-related, dopaminergic regions. cDNA… (More)
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2001
2001
Involvement of Asp-Glu-Val-Asp-directed, caspase-mediated mitogen-activated protein kinase kinase 1 Cleavage, c-Jun N-terminal kinase activation, and subsequent Bcl-2 phosphorylation for paclitaxel…
Paclitaxel is a novel anticancer drug that has demonstrated efficacy toward treating several malignant tumor types. Here, we… (More)
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Highly Cited
1999
Highly Cited
1999
Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblasts.
The mitogen-activated protein kinase (MAPK) cascade is required for mitogenesis in somatic mammalian cells and is activated by a… (More)
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Highly Cited
1997
Highly Cited
1997
The p42/p44 mitogen-activated protein kinase cascade is determinant in mediating activation of the Na+/H+ exchanger (NHE1 isoform) in response to growth factors.
The ubiquitously expressed Na+/H+ exchanger NHE1 is the target of multiple signaling pathways, including those activated by… (More)
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1995
1995
Hypertrophic agonists stimulate the activities of the protein kinases c-Raf and A-Raf in cultured ventricular myocytes.
We detected expression of two Raf isoforms, c-Raf and A-Raf, in neonatal rat heart. Both isoforms phosphorylated, activated, and… (More)
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