Loss of Chromosome 5q

Known as: 5q Deletion, 5q-, del(5q) 
A cytogenetic abnormality that refers to deletion of part of the long arm of chromosome 5. It is associated with the development of myelodysplastic… (More)
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
PURPOSE To determine the frequency of TP53 mutations and the level of p53 protein expression by immunohistochemistry (IHC) in low… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND The in vivo clinical significance of malignant stem cells remains unclear. METHODS Patients who have the 5q deletion… (More)
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Highly Cited
2009
Highly Cited
2009
Lenalidomide is the first karyotype-selective therapeutic approved for the treatment of myelodysplastic syndromes (MDS) owing to… (More)
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Highly Cited
2008
Highly Cited
2008
Somatic chromosomal deletions in cancer are thought to indicate the location of tumour suppressor genes, by which a complete loss… (More)
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Highly Cited
2008
Highly Cited
2008
Lenalidomide is approved for red blood cell (RBC) transfusion-dependent anemia due to low or intermediate-1 (int-1) risk… (More)
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Highly Cited
2007
Highly Cited
2007
Interstitial loss of all or part of the long arm of chromosome 5, or del(5q), is a frequent clonal chromosomal abnormality in… (More)
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Highly Cited
2007
Highly Cited
2007
Loss of a whole chromosome 5 or a deletion of the long arm, del(5q), is a recurring abnormality in myelodysplastic syndromes… (More)
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Highly Cited
2007
Highly Cited
2007
Myelodysplastic syndromes (MDSs) are a group of hematopoietic stem cell disorders characterized by ineffective hematopoiesis and… (More)
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Highly Cited
2002
Highly Cited
2002
The 5q- syndrome is the most distinct of the myelodysplastic syndromes, and the molecular basis for this disorder remains unknown… (More)
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Highly Cited
1998
Highly Cited
1998
Cytogenetics is considered one of the most valuable prognostic determinants in acute myeloid leukemia (AML). However, many… (More)
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